Prediction of long-term disability in multiple sclerosis
Prediction of long-term disability in multiple sclerosis
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DOI：
10.1177/1352458511416836
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发表时间：
2012-01-01
影响因子：
5.8
通讯作者：
Fuhr, P.
中科院分区：
文献类型：
--
作者：
Schlaeger, R.;D'Souza, M.;Fuhr, P.
背景资料：神经生理学指标对多发性硬化症（MS）长期病程的预测价值知之甚少。目的：前瞻性研究联合视觉（VEP）和运动诱发电位（MEP）是否可以预测14年以上的残疾。共30例复发缓解型和继发进展型MS患者接受了VEP前瞻性研究，在入组时（T0）和6、12和24个月后进行MEP和扩展残疾状态量表（EDSS），并在入组时进行头颅MRI扫描（T2加权和钆增强T1加权图像）。在第14年（T4）再次评估EDSS。诱发电位（EP）、磁共振（MR）数据与EDSS之间的相关性采用斯皮尔曼等级相关进行测量。进行多变量线性回归以预测EDSST 4作为z转换的EP-乳酸（T0）的函数。结果：EDSS值（T4）与Z转换的EP-乳酸（T0）之和（rho 0.68，p <0.01）相关，P <0.05，P <0.01，P
Background: Little is known about the predictive value of neurophysiological measures for the long-term course of multiple sclerosis (MS).Objective: To prospectively investigate whether combined visual (VEP) and motor evoked potentials (MEP) allow prediction of disability over 14 years.Methods: A total of 30 patients with relapsing-remitting and secondary progressive MS were prospectively investigated with VEPs, MEPs and the Expanded Disability Status Scale (EDSS) at entry (T0) and after 6, 12 and 24 months, and with cranial MRI scans at entry (T2-weighted and gadolinium-enhanced T1-weighted images). EDSS was again assessed at year 14 (T4). The association between evoked potential (EP), magnetic resonance (MR) data and EDSS was measured using Spearman's rank correlation. Multivariable linear regression was performed to predict EDSST4 as a function of z-transformed EP-latencies(T0). The model was validated using a jack-knife procedure and the potential for improving it by inclusion of additional baseline variables was examined.Results: EDSS values(T4) correlated with the sum of z-transformed EP-latencies(T0) (rho 0.68, p