Prevalence and transmission of mobilized colistin resistance (mcr) gene in bacteria common to animals and humans
Prevalence and transmission of mobilized colistin resistance (mcr) gene in bacteria common to animals and humans
复制标题
动物和人类常见细菌中动员型粘菌素抗性 (mcr) 基因的流行和传播
DOI：
10.1016/j.bsheal.2020.05.001
复制
发表时间：
2020-06-01
影响因子：
--
通讯作者：
Xiao, Yonghong
中科院分区：
文献类型：
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作者：
Luo, Qixia;Wang, Yuan;Xiao, Yonghong
粘菌素是一种古老的抗菌药物，已被振兴为针对多药耐药（MDR）革兰氏阴性细菌感染的最后治疗手段。然而，粘菌素已广泛应用于农业生产和兽医学几十年，最近全球范围内从动物到人类的动员粘菌素耐药（mcr）基因的传播严重威胁了粘菌素的临床应用。大多数携带mcr的分离株是肠杆菌科，如大肠杆菌和肠道沙门氏菌，它们在动物和人类中很常见。了解mcr基因在动物和人类常见细菌中的起源、传播和传播，将有助于管理粘菌素的使用和相关干预措施，以防止耐药性的进一步传播。本综述旨在提供一个全面的评估全球流行和传播的mcr基因的动物和人类肠道/病原菌。(c)2020中华医学会出版社。由爱思唯尔公司出版。这是一篇开放获取的文章，获得了CC BY-NC-ND许可证（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Colistin is an old antimicrobial that has been revitalized as last-resort treatment against multidrug-resistant (MDR) gram-negative bacterial infections. However, colistin has been widely used in agricultural production and veterinary medicine for decades, and the recent global dissemination of mobilized colistin resistance (mcr) genes from animals to humans seriously threats the clinical use of colistin. Most of the mcr-harboring isolates have been Enterobacteriaceae, such as Escherichia coli and Salmonella enterica which are common to animals and humans. An understanding of the or-igin, dissemination and transmission of mcr genes in bacteria common to animals and humans will facilitate the man-agement of colistin use and relevant interventions to prevent further spread of resistance. This review aims to provide a comprehensive assessment of the global prevalence and transmission of mcr genes of animal and human commensal/ pathogenic bacteria. (c) 2020 Chinese Medical Association Publishing House. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).