Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging
Apparent diffusion coefficient and intravoxel incoherent motion-diffusion kurtosis model parameters in invasive breast cancer: Correlation with the histological parameters of whole-slide imaging
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DOI：
10.1016/j.mri.2022.04.003
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发表时间：
2022-04-23
影响因子：
2.5
通讯作者：
Takase, Kei
中科院分区：
文献类型：
--
作者：
Mori, Naoko;Inoue, Chihiro;Takase, Kei
目的：探讨ADC和IVIM扩散峰度(DK)模型参数与全幻灯片成像定量组织学参数的相关性。方法：回顾性研究(2015年9月~2016年7月)37例乳腺浸润性导管癌患者，均为女性，中位年龄：，41~82岁，均为单发乳腺浸润性导管癌，术前MRI表现为肿块。行弥散加权成像，b值分别为0、50、100、300、550、850和1000 S/mm(2)。得到b值分别为50和850 S/mm~2的ADC图。用以下公式分析IVIM-DK模型：S(B)=S(0){Fe-(Bd)*+(1-f)e((-bd+1/6k(Bd)2))}其中S是信号强度，b是b值，f是灌注分数，D*是血管成分的伪扩散系数，D是非血管成分的扩散系数，k是扩散峰度。对肿瘤进行整体分割，获得平均ADC值、f、D*、D和k。用细胞角蛋白免疫组织化学染色和WSI获得定量的组织学参数。结果：ADC值与间质面积比(r=0.53，p=0.00082)和熵(r=-0.58，p=0.00019)呈显著正相关。K与癌细胞核面积比呈显著正相关(r=0.53，p=0.00079)。结论：由于ADC值反映的是间质面积与熵的面积比，弥散峰度反映的是癌细胞核面积比，这些参数对乳腺良、恶性肿块的鉴别和乳腺癌的分级可能是有效的。
Objectives: To evaluate the correlation of ADC and IVIM-diffusion kurtosis (DK) model parameters with quantitative histological parameters of whole-slide imaging (WSI).& nbsp;Methods: This retrospective study (September 2015-July 2016) included 37 consecutive patients (all females; median age: 64 years, range, 41-82 years), each with a single invasive breast ductal carcinoma lesion with a mass appearance on preoperative MRI. DWI with b-values of 0, 50, 100, 300, 550, 850, and 1000 s/mm(2) was performed. ADC maps were generated with b-values of 50 and 850 s/mm2. The IVIM-DK model was analysed using the following formula:& nbsp;S(b) = S(0) {fe-( bD)* + (1 -f) e((-bD+1/6k(bD)2 )) }& nbsp;where S is the signal intensity, b is the b-value, f is the perfusion fraction, D* is the pseudo-diffusion coefficient of the vascular component, D is the diffusion coefficient of the non-vascular component, and k is the diffusion kurtosis. Whole tumour segmentation was performed to obtain the mean ADC, f, D*, D, and k. Quantitative histological parameters were obtained using cytokeratin immunostaining and WSI. The correlation of ADC and IVIM-DK model parameters with quantitative histological parameters was examined by Pearson's correlation.& nbsp;Results: The ADC was significantly correlated with the area ratio of interstitium (r = 0.53, p = 0.00082) and entropy (r =-0.58, p = 0.00019). k was significantly correlated with the area ratio of cancer cell nuclei (r = 0.53, p = 0.00079).& nbsp;Conclusions: Since the ADC reflected the area ratio of interstitium and entropy, and diffusion kurtosis reflected the area ratio of cancer cell nuclei, these parameters may be effective in distinguishing between benign and malignant breast tumours and in grading breast cancer.