The burden of complex genetics in brain disorders
The burden of complex genetics in brain disorders
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DOI：
10.1001/archpsyc.61.3.223
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发表时间：
2004-03-01
影响因子：
--
通讯作者：
Grow, RW
中科院分区：
文献类型：
--
作者：
Uhl, GR;Grow, RW
背景：很少有数据估计复杂遗传学在神经精神疾病中的影响，这使得这种影响可能被低估。目的：根据美国社会的疾病成本、疾病遗传性和孟德尔对疾病的贡献，估计复杂遗传学对美国神经精神疾病的影响。数据来源、研究选择和数据提取：成本估计来自文献来源和Lewin-National Foundation for Brain Research，根据人口增长和消费者价格指数通胀进行了更新。遗传率估计来自于现有的双胞胎数据。孟德尔贡献的估计来自于在线孟德尔遗传数据库和我们的观点。结论：大脑和神经系统疾病每年给美国造成的损失可能高达1.2万亿美元，每年影响数百万美国人。双胞胎数据表明，超过40%的脑部疾病的社会负担可能是由遗传介导的。这种疾病负担大多来自复杂的多基因遗传以及环境影响。这些复杂遗传负担的巨大规模应该鼓励仔细的分子和临床工作，将疾病易感性等位基因变异与脑疾病的发病机制、病理性特征、预防、诊断和治疗联系起来。
Background: Few data estimate the impact of complex genetics in neuropsychiatric illness, making it likely that this impact could be underappreciated.Objective: To provide estimates of the impact of complex genetics in neuropsychiatric disorders in the United States, based on estimates of disease costs to US society, disease heritability, and mendelian contributions to disease.Data Sources, Study Selection, and Data Extraction: Costs were estimated from literature sources and Lewin-National Foundation for Brain Research estimates updated for population growth and consumer price index inflation. Heritability estimates came from available twin data. Estimates of mendelian contributions came from the Online Mendelian Inheritance in Man database and our perspectives.Conclusions: Brain and nervous system disorders may cost the United States as much as $1.2 trillion annually, and affect many millions of Americans each year. Twin data suggest that more than 40% of the societal burden of brain disorders is likely to be genetically mediated. Most of this disease burden arises from complex multigene genetics as well as from environmental influences. The large sizes of these complex genetic burdens should encourage careful molecular and clinical work to link disease-vulnerability allelic variants with the pathogenesis, nosologic characteristics, prevention, diagnostics, and therapeutics of brain disorders.