Targeted Nutrient Modifications in Purified Diets Differentially Affect Nonalcoholic Fatty Liver Disease and Metabolic Disease Development in Rodent Models
Targeted Nutrient Modifications in Purified Diets Differentially Affect Nonalcoholic Fatty Liver Disease and Metabolic Disease Development in Rodent Models
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DOI：
10.1093/cdn/nzaa078
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发表时间：
2020-06-01
影响因子：
4.8
通讯作者：
Pellizzon, Michael A.
中科院分区：
文献类型：
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作者：
Radhakrishnan, Sridhar;Ke, Jia-Yu;Pellizzon, Michael A.
非酒精性脂肪性肝病（NAFLD）是一系列复杂的疾病，从简单的良性脂肪变性到更具侵袭性的非酒精性脂肪性肝炎（NASH）和纤维化。虽然并非每个NAFLD/NASH患者都会出现肝脏并发症，但如果不及时治疗，最终可能导致肝硬化和肝细胞癌。用特定营养成分配制的纯化饮食可以在啮齿动物模型中驱动整个NAFLD谱。尽管它们可能不能完美地复制人类NAFLD的临床和组织学特征，但它们提供了一个模型，以进一步了解人类疾病的进展。由于NAFLD研究对饮食的需求不断增长，以及为了进一步了解饮食成分的操作如何改变疾病的发展，我们概述了啮齿动物模型（包括小鼠，大鼠和仓鼠）的几种常用饮食方法，疾病发展所需的时间范围以及是否发生与人类NAFLD相关的其他代谢疾病。
Nonalcoholic fatty liver disease (NAFLD) is a complex spectrum of disorders ranging from simple benign steatosis to more aggressive forms of nonalcoholic steatohepatitis (NASH) and fibrosis. Although not every patient with NAFLD/NASH develops liver complications, if left untreated it may eventually lead to cirrhosis and hepatocellular carcinoma. Purified diets formulated with specific nutritional components can drive the entire spectrum of NAFLD in rodent models. Although they may not perfectly replicate the clinical and histological features of human NAFLD, they provide a model to gain further understanding of disease progression in humans. Owing to the growing demand of diets for NAFLD research, and for our further understanding of how manipulation of dietary components can alter disease development, we outlined several commonly used dietary approaches for rodent models, including mice, rats, and hamsters, time frames required for disease development and whether other metabolic diseases commonly associated with NAFLD in humans occur.