INACTIVATION OF THE INFRALIMBIC PREFRONTAL CORTEX IN RATS REDUCES THE INFLUENCE OF INAPPROPRIATE HABITUAL RESPONDING IN A RESPONSE-CONFLICT TASK
INACTIVATION OF THE INFRALIMBIC PREFRONTAL CORTEX IN RATS REDUCES THE INFLUENCE OF INAPPROPRIATE HABITUAL RESPONDING IN A RESPONSE-CONFLICT TASK
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DOI：
10.1016/j.neuroscience.2011.09.065
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发表时间：
2011-12-29
期刊：
影响因子：
3.3
通讯作者：
Killcross, S.
中科院分区：
文献类型：
--
作者：
Haddon, J. E.;Killcross, S.
先前的研究表明，当目标导向和习惯性反应之间存在竞争时，边缘下皮层是重要的。在这里，我们使用了一个反应冲突的程序，以进一步探讨这种关系的边缘下皮层的参与。大鼠在两种不同的背景下接受了两种工具性双盲辨别训练，一种是听觉的，一种是视觉的。一种歧视是“训练过度”，另一种是“训练不足”，比例为3：1。在测试中，动物呈现不一致的视听刺激化合物的训练刺激在训练不足的情况下。这些测试化合物的刺激元素先前已经在训练期间决定了不同的杠杆按压响应。接受控制注入到边缘下皮层的大鼠表现出显着的干扰效应，产生更多的反应过度训练（习惯性），但上下文不适当的，刺激元素的不一致的化合物。这种干扰效应被取消的边缘下皮层的失活，动物表现出减少的趋势，产生习惯性的，但不适当的反应相比，接受控制输注的动物。这一发现提供了证据表明，边缘下皮层参与减弱目标导向行为的影响，例如上下文适当的反应。(C)2011年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Previous research suggests the infralimbic cortex is important in situations when there is competition between goal-directed and habitual responding. Here we used a response conflict procedure to further explore the involvement of the infralimbic cortex in this relationship. Rats received training on two instrumental biconditional discriminations, one auditory and one visual, in two distinct contexts. One discrimination was "over-trained" relative to the other, "under-trained," discrimination in the ratio 3:1. At test, animals were presented with incongruent audiovisual stimulus compounds of the training stimuli in the under-trained context. The stimulus elements of these test compounds have previously dictated different lever press responses during training. Rats receiving control infusions into the infralimbic cortex showed a significant interference effect, producing more responses to the over-trained (habitual), but context-inappropriate, stimulus element of the incongruent compound. This interference effect was abolished by inactivation of the infralimbic cortex; animals showed a reduced tendency to produce the habitual but inappropriate response compared with animals receiving control infusions. This finding provides evidence that the infralimbic cortex is involved in attenuating the influence of goal-directed behavior, for example context-appropriate responding. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.