Pachychoroid neovasculopathy: aspect on optical coherence tomography angiography
Pachychoroid neovasculopathy: aspect on optical coherence tomography angiography
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DOI：
10.1111/aos.13221
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发表时间：
2017-06-01
影响因子：
3.4
通讯作者：
Lumbroso, Bruno
中科院分区：
文献类型：
--
作者：
Azar, Georges;Wolff, Benjamin;Lumbroso, Bruno
PurposeTo描述和解释的特点，厚脉络膜新生血管病变（PNV）使用光学相干断层扫描血管造影术（OCTA）techniques.MethodsThis是一个观察病例系列的患者谁提出PNV。对所有患者进行最佳矫正视力（BCVA）、眼前节检查、散瞳眼底镜检查、红外和自体荧光眼底图像以及光谱域光学相干断层扫描（SD-OCT; B扫描、en-face'和OCTA）。采用增强深度成像（EDI）模式测量脉络膜厚度。没有系统地进行彩色眼底照片、荧光素眼底血管造影（FFA）和吲哚菁绿色血管造影（ICGA）。光学相干断层扫描血管造影（OCTA）的功能PNV.Results5例患者的平均年龄为62.2岁（范围，53- 73岁）的PNV进行了分析。EDI-OCT检查均表现为脉络膜增厚、脉络膜血管扩张的厚脉络膜色素上皮病变（PPE）。3例患者行荧光素眼底血管造影（FFA）检查，显示多个区域的视网膜色素上皮萎缩和眼底病变，提示慢性中心性浆液性脉络膜视网膜病变。1例患者的吲哚菁绿色血管造影（ICGA）证实了在新生血管组织区域下方观察到的脉络膜大静脉和脉络膜通透性过高。两眼在新生血管组织内有息肉样结构的外观，B超和正面都有息肉样病变的特征性表现。光学相干断层扫描血管造影（OCTA）显示的外观纠结的丝状血管网在所有的眼睛。结论光学相干断层扫描血管造影（OCTA）是一种安全的，高度敏感和特异性的检查检测1型新生血管与PPE。特征是缠绕的丝状血管覆盖在增厚的脉络膜的焦点区域上。
PurposeTo describe and interpret the features of pachychoroid neovasculopathy (PNV) using optical coherence tomography angiography (OCTA) technique.MethodsThis is an observational case series of patients who presented with PNV. Best-corrected visual acuity (BCVA), anterior segment examination, dilated funduscopic examination, infrared and autofluorescence fundus images and spectral-domain optical coherence tomography (SD-OCT; B-scan, en-face' and OCTA) were carried out for all patients. Choroid thickness was measured using enhanced depth imaging (EDI) mode. Colour fundus photographs, fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) were not performed systematically. Optical coherence tomography angiography (OCTA) features of PNV are described and interpreted.ResultsFive eyes of five patients with a mean age of 62.2years (range, 53-73years) presenting with PNV were analysed. They all presented pachychoroid pigment epitheliopathy (PPE) with choroidal thickening and dilated choroidal vessels as seen with EDI-OCT. Fluorescein angiography (FFA) was performed in three patients showing multiple areas of retinal pigment epithelium atrophy and fundus lesions suggestive of chronic central serous chorioretinopathy. Indocyanine green angiography (ICGA) in one patient confirmed the presence of large choroidal veins and choroidal hyperpermeability seen beneath the area of the neovascular tissue. Two eyes had the appearance of polypoidal structures within the neovascular tissue, with the characteristic aspect of the polypoidal lesions on B-scan and en-face'. Optical coherence tomography angiography (OCTA) showed the appearance of tangled filamentous vascular network in all eyes.ConclusionOptical coherence tomography angiography (OCTA) is a safe, highly sensitive and specific examination for the detection of type 1 neovascularization associated with PPE. Features are characteristic of tangled filamentous vessels overlying a focal area of thickened choroid.