Panax ginseng Protects Against Global Ischemia Injury in Rat Hippocampus
Panax ginseng Protects Against Global Ischemia Injury in Rat Hippocampus
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DOI：
10.1089/jmf.2007.0614
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发表时间：
2009-02-01
影响因子：
2.4
通讯作者：
Kang, Soon Ah
中科院分区：
文献类型：
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作者：
Kim, Young Ock;Kim, Hak-Jae;Kang, Soon Ah
在利用人参C.A. Meyer（五加科）在传统韩医学中用于治疗中风，本研究使用四血管闭塞大鼠模型评价人参在短暂性全脑缺血后的神经保护作用。采用Nissl染色、脑组织脂质过氧化（丙二醛[MDA]生成）、超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）活性测定。乙醇人参提取物（200 mg/kg，i. p.）如通过测量神经元细胞的密度所证明的，显著保护CA 1神经元免受10分钟的短暂前脑缺血。人参还能显著降低MDA含量，增加GPx和SOD的表达。提示人参可能通过降低脂质过氧化物、增加GPx和SOD的表达而对脑缺血损伤具有神经保护作用。
Based on the use of Panax ginseng C.A. Meyer (Family Araliaceae) for the treatment of stroke in traditional Korean medicine, the present study was carried out to evaluate neuroprotective effects of P. ginseng after transient global cerebral ischemia using the four-vessel occlusion rat model. Nissl staining, lipid peroxidation (malondialdehyde [MDA] formation), and activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) of rat brain were assessed. Ethanolic P. ginseng extract (200 mg/kg, i.p.) significantly protected CA1 neurons against 10 minutes of transient forebrain ischemia as demonstrated by measuring the density of neuronal cells. P. ginseng also significantly decreased the level of MDA and increased the expression of GPx and SOD. These results suggest that P. ginseng might be neuroprotective against cerebral ischemia-induced injury in rat brain by decreasing lipid peroxides and increasing the expression of GPx and SOD.