Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women
Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women
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DOI：
10.1016/j.nutres.2012.09.002
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发表时间：
2012-10-01
影响因子：
4.5
通讯作者：
Maeda, Seiji
中科院分区：
文献类型：
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作者：
Akazawa, Nobuhiko;Choi, Youngju;Maeda, Seiji
血管内皮功能随着年龄的增长而下降，并与心血管疾病的风险增加有关。生活方式的改变，特别是有氧运动和饮食的调整，对血管衰老有良好的影响。姜黄素是姜黄的主要成分，具有抗炎和抗氧化作用。我们研究了姜黄素摄入和有氧运动训练对血流介导的扩张的影响，作为绝经后妇女内皮功能的指标。32名绝经后妇女被分为3组：对照组、运动组和姜黄素组。姜黄素组口服姜黄素8周。运动组进行8周的适度有氧运动训练。在每次干预前后，测量血流介导的扩张。各组之间在基线血流介导的舒张或其他关键因变量方面没有差异。在姜黄素组和运动组中，血流介导的舒张明显增加，而在对照组中没有观察到变化。我们的研究结果表明，姜黄素摄入和有氧运动训练可以增加绝经后妇女血流介导的扩张，这表明两者都可以潜在地改善与年龄相关的内皮功能下降。(C) 2012爱思唯尔公司版权所有。
Vascular endothelial function is declines with aging and is associated with an increased risk of cardiovascular disease. Lifestyle modification, particularly aerobic exercise and dietary adjustment, has a favorable effect on vascular aging. Curcumin is a major component of turmeric with known anti-inflammatory and anti-oxidative effects. We investigated the effects of curcumin ingestion and aerobic exercise training on flow-mediated dilation as an indicator endothelial function in postmenopausal women. A total of 32 postmenopausal women were assigned to 3 groups: control, exercise, and curcumin groups. The curcumin group ingested curcumin orally for 8 weeks. The exercise group underwent moderate aerobic exercise training for 8 weeks. Before and after each intervention, flow-mediated dilation was measured. No difference in baseline flow-mediated dilation or other key dependent variables were detected among the groups. Flow-mediated dilation increased significantly and equally in the curcumin and exercise groups, whereas no changes were observed in the control group. Our results indicated that curcumin ingestion and aerobic exercise training can increase flow-mediated dilation in postmenopausal women, suggesting that both can potentially improve the age-related decline in endothelial function. (C) 2012 Elsevier Inc. All rights reserved.