SULFONYLUREAS - A NEW CLASS OF CANCER CHEMOTHERAPEUTIC-AGENTS
SULFONYLUREAS - A NEW CLASS OF CANCER CHEMOTHERAPEUTIC-AGENTS
复制标题
DOI：
10.1021/jm00094a013
复制
发表时间：
1992-08-07
影响因子：
7.3
通讯作者：
GRINDEY, GB
中科院分区：
文献类型：
--
作者：
MOHAMADI, F;SPEES, MM;GRINDEY, GB
本研究总结了一些硫代噻吩类似物对皮下植入的6C 3 HED淋巴肉瘤的抗肿瘤特性与二芳基磺酰脲的磺酰胺部分的芳基结构修饰。还提供了N-（对氯苯基）-N '-[（5-甲氧基-2-噻吩基）磺酰基]脲在HXGC 3、VRC 5、CX-1和LX-1细胞系中的活性谱。
This study summarizes the antitumor properties of a number of sulofenur thiophene analogs against subcutaneously implanted 6C3HED lymphosarcoma with structural modification of the aryl moiety of the sulfonamide portion of the diarylsulfonylureas. The spectrum of activity of N-(p-chlorophenyl)-N'-[(5-methoxy-2-thienyl)sulfonyl]urea in the HXGC3, VRC5, CX-1, and LX-1 cell lines is also presented.