Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence
Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence
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DOI：
10.1002/anie.201204087
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发表时间：
2012-01-01
影响因子：
16.6
通讯作者：
Hertweck, Christian
中科院分区：
文献类型：
--
作者：
Xu, Zhongli;Baunach, Martin;Hertweck, Christian
使吲哚类化合物成形：遗传分析、途径解剖和异源重组提供了对细菌吲哚类四萜生物合成的第一次洞察，并揭示了一种新型的萜类环酶和吲哚加氧酶参与了吲哚类、夏霉素和皂苷环系统的形成。此外，异源途径的表达导致了CC和CN连接的夏霉素二聚体的发现。
Getting indole terpenes into shape: Genetic analysis, pathway dissection, and heterologous reconstitution provide first insights into bacterial indolosesquiterpenoid biosynthesis and unveil the involvement of a new type of terpene cyclase and an indole oxygenase in the formation of indosespene, xiamycin, and sespenine ring systems. Furthermore, heterologous pathway expression led to the discovery of CC-and CN-linked xiamycin dimers.