Age-dependency of sevoflurane-induced electroencephalogram dynamics in children
Age-dependency of sevoflurane-induced electroencephalogram dynamics in children
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DOI：
10.1093/bja/aev114
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发表时间：
2015-07-01
影响因子：
9.8
通讯作者：
Purdon, P. L.
中科院分区：
文献类型：
--
作者：
Akeju, O.;Pavone, K. J.;Purdon, P. L.
背景：全身麻醉诱导成人脑电图（EEG）高度结构化振荡，但麻醉诱导的儿童脑电图尚不清楚。神经回路在发育过程中经历结构和功能的转变，这可能反映在麻醉引起的脑电图振荡中。因此，我们研究了儿童患者在七氟醚全身麻醉期间脑电图的年龄相关变化。方法：采用功率谱法和相干法对54例0 ~ 28岁患者在常规护理过程中记录的脑电图进行分析。功率谱量化了每个频率下脑电信号的能量，而相干性衡量了不同头皮位置的脑电信号之间的频率相关或同步。我们将脑电图作为年龄的函数进行表征，并将其分为5个年龄组：6-14岁（n=14）， >14-21岁（n=11）， >21-28岁（n=13）。结果：从婴儿期到6岁左右，脑电图功率显著增加，随后在大约21岁时下降到平台期。与七氟醚诱导的成人无意识相关的显著脑电图特征α (8-13 Hz)相干性在患者中不存在
Background: General anaesthesia induces highly structured oscillations in the electroencephalogram (EEG) in adults, but the anaesthesia-induced EEG in paediatric patients is less understood. Neural circuits undergo structural and functional transformations during development that might be reflected in anaesthesia-induced EEG oscillations. We therefore investigated age-related changes in the EEG during sevoflurane general anaesthesia in paediatric patients.Methods: We analysed the EEG recorded during routine care of patients between 0 and 28 yr of age (n=54), using power spectral and coherence methods. The power spectrum quantifies the energy in the EEG at each frequency, while the coherence measures the frequency-dependent correlation or synchronization between EEG signals at different scalp locations. We characterized the EEG as a function of age and within 5 age groups: 6-14 yr old(n=14), >14-21 yr old(n=11), >21-28 yr old(n=13).Results: EEG power significantly increased from infancy through similar to 6 yr, subsequently declining to a plateau at approximately 21 yr. Alpha (8-13 Hz) coherence, a prominent EEG feature associated with sevoflurane-induced unconsciousness in adults, is absent in patients