Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
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DOI：
10.3389/fcell.2020.00773
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发表时间：
2020-08
影响因子：
5.5
通讯作者：
Holly N. Wilkinson;M. Hardman
中科院分区：
文献类型：
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作者：
Holly N. Wilkinson;M. Hardman
细胞衰老是抑制肿瘤形成的基本应激反应。然而，衰老细胞也存在于非癌状态，随着年龄的增长呈指数级积累，并导致与年龄和糖尿病相关的细胞功能障碍。曾经被认为是无功能的细胞中的过度分泌和吞噬行为的鉴定导致了最近衰老研究的爆炸。在这里，我们讨论了深刻的，往往是相反的，短期与慢性组织衰老确定的作用。短暂诱导的衰老是发育、再生和急性创伤修复所必需的，而慢性衰老广泛涉及组织病理学。我们最近证明，持续的衰老通过CXCR2受体促进糖尿病愈合受损，当CXCR2受体被阻断时，促进修复。进一步的研究强调了针对一系列与衰老相关的过程来对抗疾病的有益效果。总的来说，这些发现为开发临床可行的策略以解决慢性伤口和其他皮肤病理中的衰老问题提供了希望。
Cellular senescence is a fundamental stress response that restrains tumour formation. Yet, senescence cells are also present in non-cancerous states, accumulating exponentially with chronological age and contributing to age- and diabetes-related cellular dysfunction. The identification of hypersecretory and phagocytic behaviours in cells that were once believed to be non-functional has led to a recent explosion of senescence research. Here we discuss the profound, and often opposing, roles identified for short-lived vs. chronic tissue senescence. Transiently induced senescence is required for development, regeneration and acute wound repair, while chronic senescence is widely implicated in tissue pathology. We recently demonstrated that sustained senescence contributes to impaired diabetic healing via the CXCR2 receptor, which when blocked promotes repair. Further studies have highlighted the beneficial effects of targeting a range of senescence-linked processes to fight disease. Collectively, these findings hold promise for developing clinically viable strategies to tackle senescence in chronic wounds and other cutaneous pathologies.