Recent advances in Tourette syndrome.
Recent advances in Tourette syndrome.
复制标题
DOI：
10.1097/wco.0b013e328344648c
复制
发表时间：
2011-04
影响因子：
4.8
通讯作者：
Pittenger C
中科院分区：
文献类型：
--
作者：
Bloch M;State M;Pittenger C
本综述的目的是考虑最近的文献有关神经生物学，遗传学和治疗抽动秽语综合征（TS）。在过去的几年里，神经病理学和遗传学的发现都进一步关注了长期存在的关于基底神经节在抽搐和TS病因学中的作用的假设。此外，虽然该领域正在等待第一次大规模遗传研究的结果，但最近的发现已经更广泛地反映了神经精神遗传学文献的发展。突出罕见变异研究的价值和重叠的风险在看似不同的诊断类别。最后，治疗研究强调了认知行为和药物干预对抽动障碍治疗的重要性。最近的发现导致了关于TS的分子和细胞机制的新颖的，可测试的假设，这些，反过来，已经开始为概念化治疗策略提供新的途径。虽然迫切需要开发额外的药物选择，但最近的数据已经证明了非药物方法的安全性和有效性。
The purpose of this review is to consider the recent literature pertaining to the neurobiology, genetics and treatment of Tourette syndrome (TS). Over the last several years, both neuropathological and genetic findings have further focused attention on long-standing hypotheses regarding the role of the basal ganglia in the etiology of tics and TS. Moreover, while the field awaits the results the first large-scale genetic studies, recent findings have already mirrored developments in the neuropsychiatric genetics literature more broadly, highlighting the value of the study of rare variation and the overlap of risks among seemingly disparate diagnostic categories. Finally, treatment studies have underscored the importance of cognitive-behavioral as well as pharmacological interventions for the treatment of tic disorders. Recent findings have led to novel, testable hypotheses regarding the molecular and cellular mechanisms underlying TS. These, in turn, have begun to provide new avenues to conceptualizing treatment strategies. While the development of additional medication options is a pressing need, recent data has demonstrated both the safety and efficacy of non-pharmacological approaches.