Anesthetic Influence on Arteriolar Diameters and Tissue Oxygen Tension in Hemorrhaged Rats
Anesthetic Influence on Arteriolar Diameters and Tissue Oxygen Tension in Hemorrhaged Rats
复制标题
麻醉对失血大鼠小动脉直径和组织氧张力的影响
DOI：
10.1097/00000542-198209000-00006
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发表时间：
1982
期刊：
影响因子：
8.8
通讯作者：
I. Silver
中科院分区：
文献类型：
--
作者：
D. Longnecker;D. C. Ross;I. Silver
患者;68只出血大鼠，分别用125 mg/kg氯胺酮肌内麻醉，外加30 mg/kg的补充麻醉，或2.2%的安氟醚麻醉，测量其胸肌动脉直径和组织氧张力。在整个实验过程中，动物呼吸室内空气或室内空气加安氟醚。根据连续的分支顺序来识别肌内的小动脉，每隔30秒测量一阶、三阶和四阶血管的内径。用铂铱微电极极谱法测量Cremaster肌氧张力。出血30min时平均动脉压控制在30 - 35 mmHg，两组最大流出血容量相似（2.6 ml/100 g）。接受安氟醚治疗的大鼠出血的主要反应是1)第一、三、四阶小动脉收缩，以及2)组织缺氧。在接受氯胺酮治疗的出血大鼠中，对出血的收缩反应减弱（一级和三级小动脉）或消除（四级小动脉），并且没有发生组织缺氧。作者得出结论，与安氟醚相比，氯胺酮可以减少或防止出血大鼠肌动脉收缩和组织缺氧。
&NA; Arteriolar diameters and tissue oxygen tensions were measured in the cremaster muscles of 68 hemorrhaged rats which were anesthetized with either intramuscular ketamine, 125 mg/kg, plus 30 mg/ kg supplements as needed, or enflurane, 2.2% inspired. Animals breathed room air, or room air plus enflurane, throughout the experiments. Arterioles in the cremaster muscle were identified according to successive orders of branching, and the internal diameters of first‐, third‐, and fourth‐order vessels were measured at 30‐s intervals. Cremaster muscle oxygen tension was measured polarographically with platinum‐iridium microelectrodes. Mean arterial pressure was controlled at 30–35 mmHg during 30 min of hemorrhage, and maximum shed blood volumes were similar (2.6 ml/100 g) in both groups. Principal responses to hemorrhage in rats receiving enflurane were 1) constriction in first‐, third‐, and fourth‐order arterioles, and 2) tissue hypoxia. In hemorrhaged rats receiving ketamine, the constrictor response to hemorrhage either was diminished (first‐ and third‐order arterioles) or abolished (fourth‐order arterioles), and tissue hypoxia did not occur. The authors conclude that ketamine, as compared with enflurane, diminishes or prevents arteriolar constriction and tissue hypoxia in the cremaster muscle of hemorrhaged rats.