Individual and combined impact of lifestyle factors on atrial fibrillation in apparently healthy men and women: The EPIC-Norfolk prospective population study
Individual and combined impact of lifestyle factors on atrial fibrillation in apparently healthy men and women: The EPIC-Norfolk prospective population study
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DOI：
10.1177/2047487318782379
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发表时间：
2018-09-01
影响因子：
8.3
通讯作者：
Pfister, Roman
中科院分区：
文献类型：
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作者：
Di Benedetto, Laura;Michels, Guido;Pfister, Roman
背景生活方式因素是预防的重要目标。健康的生活方式对心房颤动的累积影响在population.Design前瞻性人群为基础的队列study.Methods四个生活方式因素（正常体重，目前不吸烟，没有或适度饮酒，身体不活跃）进行了评估，在明显健康的21,499名男性和女性年龄39-79岁参加EPIC研究在诺福克，英国。年龄和性别调整后的风险（95%置信区间）的入院诊断为房颤在平均随访17.1年分别为每个因素和健康评分包括因素与显着impacts.Results正常体重，目前不吸烟和低酒精摄入量与房颤的风险显着降低，而不缺乏身体活动则没有显示出显著的相关性。不吸烟、低酒精摄入量和体重指数25 - 27.5kg/m2各得1分，体重指数2分
Background Lifestyle factors are important targets for prevention. The cumulative impact of healthy lifestyle on atrial fibrillation in the population has not been quantified.Design Prospective population-based cohort study.Methods Four lifestyle factors (normal weight, currently not smoking, no or moderate alcohol intake, and physically not inactive) were assessed in apparently healthy 21,499 men and women aged 39-79 years participating in the EPIC study in Norfolk, UK. The age and sex-adjusted hazard (95% confidence interval) of hospital admission with a diagnosis of atrial fibrillation during an average follow-up of 17.1 years was examined for each factor separately and for a health score comprising factors with significant impact.Results Normal weight, currently not smoking and low alcohol intake were associated with a significantly lower risk of atrial fibrillation, whereas not being physically inactive showed no significant association. We used a score of one point each for not smoking, low alcohol intake and body mass index 25 to 27.5kg/m(2), and two points for body mass index