Polarization Sensitive Subcutaneous and Muscular Imaging Based on Common Path Optical Coherence Tomography Using Near Infrared Source
Polarization Sensitive Subcutaneous and Muscular Imaging Based on Common Path Optical Coherence Tomography Using Near Infrared Source
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DOI：
10.1007/s10916-009-9388-0
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发表时间：
2011-08-01
影响因子：
5.3
通讯作者：
Song, Chul Gyu
中科院分区：
文献类型：
--
作者：
Han, Jae-Ho;Kang, Jin U.;Song, Chul Gyu
在本文中，我们描述了一个偏振敏感（PS）的皮下和肌肉成像系统的基础上，共路光学相干层析成像（CP-OCT）使用近红外光源。PS-OCT系统的轴向和横向分辨率分别为9和6 μ m。本研究的主要目的是建立一种高分辨率、微创的光学成像仪，用于检测各种具有内在或形状双折射的皮肤亚结构。内部结构信息是通过实时信号分析（傅立叶变换）的调制光谱强度取决于光束和组织的双折射提取。使用新鲜牛肉最长肌和活体褐家鼠（大鼠）的初步结果表明，它是可能的，以实现上级图像对比度和灵敏度的检测隐藏的真皮结构的样品中的组织胶原纤维的双折射效应可视化。与传统的CP-OCT相比，所提出的PS-OCT系统提供了深度分辨图像，其反映了组织的双折射。
In this paper, we describe a polarization sensitive (PS) subcutaneous and muscular imaging system based on common path optical coherence tomography (CP-OCT) using a near infrared source. The axial and lateral resolutions of the PS-OCT system are 9 and 6 mu m, respectively. The main goal of this work is to build a high-resolution and minimally invasive optical imager for examining various kinds of cutaneous substructures with intrinsic or form birefringence. The internal structural information is extracted by the real-time signal analysis (Fourier Transform) of the modulated spectral intensity depending on the beam and tissue birefringence. The preliminary results using fresh beef longissimus muscle and in vivo Rattus norvegicus (rat) show that it is possible to visualize the birefringence effect of the tissue collagen fibers in the samples in order to achieve superior image contrast and sensitivity for the detection of hidden dermal structures. Compared to conventional CP-OCT, the proposed PS-OCT system provides depth-resolved images, which reflect the tissue birefringence.