Depressive Symptomatology, Exercise Adherence, and Fitness Are Associated With Reduced Cognitive Performance in Heart Failure
Depressive Symptomatology, Exercise Adherence, and Fitness Are Associated With Reduced Cognitive Performance in Heart Failure
复制标题
DOI：
10.1177/0898264312474039
复制
发表时间：
2013-04-01
影响因子：
2.8
通讯作者：
Gunstad, John
中科院分区：
文献类型：
--
作者：
Alosco, Michael L.;Spitznagel, Mary Beth;Gunstad, John
目的：抑郁是心力衰竭（HF）患者常见的并发症，并与认知功能下降有关。目前的研究使用结构方程模型来研究抑郁症是否通过对运动依从性和心血管健康的不利影响而对HF的认知功能产生不利影响。方法：158名HF患者完成了神经心理学测试、体能测试、Beck抑郁量表-II（BDI-II）以及评估运动坚持性和体力消耗的措施。结果如下：该模型表现出良好的模型拟合和BDI-II评分增加，对运动依从性和心血管健康产生负面影响。心血管健康和认知功能之间存在很强的负相关。Sobel测试显示BDI-II和认知功能之间通过心血管适应性存在显著的间接途径。讨论：本研究表明HF中的抑郁可能通过降低心血管健康对认知功能产生不利影响。需要前瞻性研究来确定抑郁症治疗是否可以导致更好的生活方式行为，并最终改善HF的神经认知结局。
Objective: Depression is common in heart failure (HF) and associated with reduced cognitive function. The current study used Structrual Equation Modeling to examine whether depression adversely impacts cognitive function in HF through its adverse affects on exercise adherence and cardiovascular fitness. Method: 158 HF patients completed neuropsychological testing, physical fitness test, Beck Depression Inventory-II (BDI-II), and measures assessing exercise adherence and physical exertion. Results: The model demonstrated excellent model fit and increased scores on the BDI-II negatively affected exercise adherence and cardiovascular fitness. There was a strong inverse association between cardiovascular fitness and cognitive function. Sobel test showed a significant indirect pathway between the BDI-II and cognitive function through cardiovascular fitness. Discussion: This study suggests depression in HF may adversely impact cognitive function through reduced cardiovascular fitness. Prospective studies are needed to determine whether treatment of depression can lead to better lifestyle behaviors and ultimately improve neurocognitive outcomes in HF.