Extracellular Hsp90 and protection of neuronal cells through Nrf2.
Extracellular Hsp90 and protection of neuronal cells through Nrf2.
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DOI：
10.1042/bst20210370
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发表时间：
2021-11-01
影响因子：
3.9
通讯作者：
Prince, Thomas L
中科院分区：
文献类型：
--
作者：
Calderwood, Stuart K;Borges, Thiago J;Prince, Thomas L
热休克蛋白90（Hsp 90）是细胞内最重要的分子伴侣之一，但在细胞外环境中也起着重要作用。在这里，我们回顾了细胞外热休克蛋白90在热休克反应（HSR）中的细胞内稳态的特性，重点是中枢神经系统的细胞。Hsp 90可以由小胶质细胞以及其他细胞类型通过非经典的分泌途径分泌。然后，分子伴侣可以影响远处细胞的行为，并且可以例如保护神经元细胞免受伴随β-淀粉样蛋白原纤维的小胶质细胞吞噬作用的氧化爆发。报道了涉及转录因子Nrf 2的激活和诱导抗氧化反应的机制。本文综述了细胞外Hsp 90、Nrf 2和跨细胞分子伴侣信号在非细胞内源性HSR中的作用。
Heat shock protein 90 (Hsp90), although one of the most essential intracellular chaperones, can also play key roles in the extracellular milieu. Here, we review the properties of extracellular Hsp90 in cellular homeostasis in the heat shock response (HSR), focusing on cells of the central nervous system. Hsp90 can be secreted by microglia as well as other cell types by non-canonical pathways of secretion. The chaperone may then influence the behavior of distant cells and can for instance protect neuronal cells from the oxidative burst accompanying phagocytosis by microglia of beta-amyloid fibrils. A mechanism involving activation of the transcription factor Nrf2, and induction of the antioxidant response is reported. We review the potential role of extracellular Hsp90, Nrf2 and transcellular chaperone signaling in the non-cell-intrinsic HSR.