Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction
Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction
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DOI：
10.1164/ajrccm.164.8.2105002
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发表时间：
2001-10-15
影响因子：
24.7
通讯作者：
Lomas, DA
中科院分区：
文献类型：
--
作者：
McCloskey, SC;Patel, BD;Lomas, DA
尽管家族性聚集已被描述，但很少有研究量化慢性阻塞性肺疾病(COPD)患者同胞的气流阻塞风险。152名有气流阻塞和低气体传递系数但没有PIZ(α(1)-抗胰蛋白酶缺乏症)的受试者参加了这项研究。完整的数据来自这些受试者221个兄弟姐妹中的173个。在126名现在或曾经吸烟的兄弟姐妹中，44人有气流阻塞(FEV1/FVC<；0.7)，36人也有FEV1<；80%的预测，与COPD一致。来自欧洲癌症前瞻性调查(EPIC)-诺福克队列的111名现在或曾经吸烟的兄弟姐妹在年龄、性别和吸烟史方面与419名研究对象进行了匹配，这些受试者没有已知的COPD家族史。EPIC组的COPD患病率(9.3%)远低于兄弟姐妹组(31.5%；优势比4.70；95%可信区间2.63至8.41)。与匹配的对照组受试者相比，吸烟史少于30年的兄弟姐妹患COPD的优势比为5.39(95%可信区间为2.49至11.67)。综上所述，这些结果表明，重度COPD患者吸烟的兄弟姐妹存在明显的气流阻塞的家族风险。
Although familial clustering has been described, few studies have quantified the risk of airflow obstruction in siblings of patients with chronic obstructive pulmonary disease (COPD). One hundred fifty-two subjects with airflow obstruction and a low gas transfer factor but without PiZ (alpha (1)-antitrypsin deficiency) were identified and 150 were enrolled in the study. Complete data were obtained from 173 of 221 siblings of these subjects. Forty-four of 126 current or ex-smoking siblings had airflow obstruction (FEV1/FVC < 0.7) and 36 also had a FEV1 < 80% predicted, in keeping with COPD. One hundred eleven current or ex-smoking siblings were matched for age, sex, and smoking history with 419 subjects, without a known family history of COPD, from the European Prospective Investigation of Cancer (EPIC)-Norfolk cohort. The prevalence of COPD was much lower in the EPIC group (9.3%) when compared with the siblings (31.5%; odds ratio, 4.70; 95% confidence interval, 2.63 to 8.41). The odds ratio for COPD in siblings with less than a 30 pack-year smoking history was 5.39 (95% confidence interval, 2.49 to 11.67) when compared with matched control subjects. Taken together these results demonstrate a significant familial risk of airflow obstruction in smoking siblings of patients with severe COPD.