Dynamics of particle uptake at cell membranes
Dynamics of particle uptake at cell membranes
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DOI：
10.1103/physreve.100.052403
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发表时间：
2019-11-14
影响因子：
2.4
通讯作者：
Schwarz, Ulrich S.
中科院分区：
文献类型：
--
作者：
Frey, Felix;Ziebert, Falko;Schwarz, Ulrich S.
受体介导的内吞作用要求粘附能克服质膜的变形能。由此产生的驱动力是平衡的耗散力，导致确定性的动力学方程。虽然自由膜的形状对张力膜和松散膜不起重要作用，但在中间状态下，它导致重要的能量势垒。在这里，我们表明，这种障碍是类似的，但不同于有效的线张力，并提出了一个简单的解析近似，然后，我们探讨了丰富的动态摄取不同形状的粒子，并提出相应的动态状态图。我们还扩展了我们的模型，包括随机波动，这有利于吸收，并导致相应的变化的相图。
Receptor-mediated endocytosis requires that the energy of adhesion overcomes the deformation energy of the plasma membrane. The resulting driving force is balanced by dissipative forces, leading to deterministic dynamical equations. While the shape of the free membrane does not play an important role for tensed and loose membranes, in the intermediate regime it leads to an important energy barrier. Here we show that this barrier is similar to but different from an effective line tension and suggest a simple analytical approximation for it. We then explore the rich dynamics of uptake for particles of different shapes and present the corresponding dynamical state diagrams. We also extend our model to include stochastic fluctuations, which facilitate uptake and lead to corresponding changes in the phase diagrams.