Update on amniotic membrane transplantation.
Update on amniotic membrane transplantation.
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羊膜移植最新进展
DOI：
10.1586/eop.10.63
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发表时间：
2010-10
影响因子：
0.7
通讯作者：
Tseng SC
中科院分区：
文献类型：
--
作者：
Liu J;Sheha H;Fu Y;Liang L;Tseng SC
冷冻保存的羊膜通过促进上皮形成同时抑制基质炎症、血管生成和瘢痕形成来调节成人伤口愈合。羊膜移植的这种临床疗效已在数百篇出版物中报道，用于广泛的眼科适应症。上述治疗作用的成功促使研究者使用羊膜作为替代小生境来实现眼表面上皮祖细胞的离体扩增。对羊膜发挥作用的分子机制的进一步研究无疑将揭示再生医学新兴领域的其他应用。这篇文章将集中在羊膜移植的最新进展，并扩大到涵盖其临床应用以外的眼表。
Cryopreserved amniotic membrane modulates adult wound healing by promoting epithelialization while suppressing stromal inflammation, angiogenesis and scarring. Such clinical efficacies of amniotic membrane transplantation have been reported in several hundred publications for a wide spectrum of ophthalmic indications. The success of the aforementioned therapeutic actions prompts investigators to use amniotic membrane as a surrogate niche to achieve ex vivo expansion of ocular surface epithelial progenitor cells. Further investigation into the molecular mechanism whereby amniotic membrane exerts its actions will undoubtedly reveal additional applications in the burgeoning field of regenerative medicine. This article will focus on recent advances in amniotic membrane transplantation and expand to cover its clinical uses beyond the ocular surface.