Is reduction in appetite beneficial for body weight management in the context of overweight and obesity? Yes, according to the SATIN (Satiety Innovation) study
Is reduction in appetite beneficial for body weight management in the context of overweight and obesity? Yes, according to the SATIN (Satiety Innovation) study
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DOI：
10.1017/jns.2019.36
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发表时间：
2019-01-01
影响因子：
2.5
通讯作者：
Sjodin, Anders
中科院分区：
文献类型：
--
作者：
Hansen, Thea Toft;Mead, Bethan R.;Sjodin, Anders
需要基于饮食的新概念来治疗和有效预防超重和肥胖。主要目的是调查食欲下降是否与改善减肥维持有关。这项队列研究属于欧盟委员会饱腹感创新项目 (SATIN)。在最初的 8 周低能量配方饮食中体重减轻>= 8% 的参与者被纳入为期 12 周的随机双盲平行减肥维持干预措施。干预措施包括旨在降低食欲的食品或匹配控制措施以及遵循国家饮食指南的说明。在标准化食欲探测日期间，通过随意摄入能量和使用视觉模拟量表自我报告的食欲评估来评估食欲。无论随机化如何，在维持期的第一天与基线（单次暴露于干预产品后的急性效应）相比以及维持后与基线（重复暴露于干预产品后的持续效应）相比进行评估。共有 181 名参与者（47 名男性和 134 名女性）完成了这项研究。 24 小时能量摄入的持续减少与减肥维持效果的改善相关（R 0.37；P = 0.001），但这种关联并未明显被发现（P = 0.91）。自我报告的食欲抑制与短期（R -0.32；P = 0.033）和持续（R -0.33；P = 0.042）的体重减轻维持改善相关。食欲的减少似乎与体重管理的改善有关，这使得减少食欲的食品成为基于饮食的概念的有趣策略。
New dietary-based concepts are needed for treatment and effective prevention of overweight and obesity. The primary objective was to investigate if reduction in appetite is associated with improved weight loss maintenance. This cohort study was nested within the European Commission project Satiety Innovation (SATIN). Participants achieving >= 8% weight loss during an initial 8-week low-energy formula diet were included in a 12-week randomised double-blind parallel weight loss maintenance intervention. The intervention included food products designed to reduce appetite or matching controls along with instructions to follow national dietary guidelines. Appetite was assessed by ad libitum energy intake and self-reported appetite evaluations using visual analogue scales during standardised appetite probe days. These were evaluated at the first day of the maintenance period compared with baseline (acute effects after a single exposure of intervention products) and post-maintenance compared with baseline (sustained effects after repeated exposures of intervention products) regardless of randomisation. A total of 181 participants (forty-seven men and 134 women) completed the study. Sustained reduction in 24-h energy intake was associated with improved weight loss maintenance (R 0.37; P = 0.001), whereas the association was not found acutely (P = 0.91). Suppression in self-reported appetite was associated with improved weight loss maintenance both acutely (R -0.32; P = 0.033) and sustained (R -0.33; P = 0.042). Reduction in appetite seems to be associated with improved body weight management, making appetite-reducing food products an interesting strategy for dietary-based concepts.