National surveillance of herbal dietary supplement exposures: the poison control center experience.
National surveillance of herbal dietary supplement exposures: the poison control center experience.
复制标题
国家草药膳食补充剂暴露监测：毒物控制中心的经验。
DOI：
10.1002/pds.1445
复制
发表时间：
2007
影响因子：
2.6
通讯作者：
Nisly,NicoleL
中科院分区：
文献类型：
--
作者：
Gryzlak,BrianM;Wallace,RobertB;Zimmerman,MBridget;Nisly,NicoleL
目的 本报告的目的是描述向毒物控制中心 (PCC) 提交的涉及两种广泛使用的草药膳食补充剂 (HDS) 紫锥菊和圣约翰草 (SJW) 的报告。方法我们从美国毒物控制中心协会 (AAPCC) 的毒性暴露监测系统 (TESS®) 购买了 2001 年向 PCC 提交的涉及紫锥菊或圣约翰草 (SJW) 的报告的数据。分析仅限于紫锥菊或 SJW 是唯一相关产品的情况，并且这些 HDS 被认为是观察到的不良反应的主要原因。对选定的人口统计和暴露相关变量进行了描述性统计。 结果 2001 年，PCC 就涉及紫锥菊的 406 例暴露和涉及 SJW 的 356 例暴露进行了联系。大多数报告的两种 HDS 暴露发生在 5 岁及以下儿童中，并且大多数暴露被编码为无意。对于这两种 HDS，≥20 岁的患者的暴露更有可能与不良反应相关。故意暴露占 SJW 病例的 21% 和紫锥菊病例的 3%，其中 13% 的 SJW 暴露报告为“疑似自杀”。结论 TESS® 是评估和表征 HDS 相关不良反应的潜在重要方法。验证向 TESS® 报告的暴露样本的临床事件和结果的详细研究可能会提供对不良事件 (AE) 的深入见解，这些不良事件可以与其他已建立的药物流行病学研究设计一起进行系统研究。版权所有 © 2007 约翰·威利父子有限公司
PurposeThe purpose of this report is to characterize reports to poison control centers (PCCs) involving two widely used herbal dietary supplements (HDSs),Echinacea, and St. John's wort (SJW).MethodsWe purchased data from the American Association of Poison Control Center's (AAPCC) toxic exposure surveillance system (TESS®) on reports made to PCCs in 2001 involvingEchinaceaor SJW. Analyses were limited to those cases in whichEchinaceaor SJW were the only associated products, and in which these HDSs were deemed primary to observed adverse effects. Descriptive statistics were generated for selected demographic and exposure‐related variables.ResultsDuring 2001, PCCs were contacted regarding 406 exposures involvingEchinaceaand 356 exposures involving SJW. Most of the reported exposures for both HDSs occurred among children 5 years and younger, and the majority of exposures were coded as unintentional. For both HDSs, exposures among patients ≥20 years old were more likely to be associated with adverse effects. Intentional exposures accounted for 21% of SJW cases and 3% ofEchinaceacases, with 13% of SJW exposures reported as ‘suspected suicidal’.ConclusionsTESS® represents a potentially important means of assessing and characterizing HDS‐related adverse effects. Detailed studies validating the clinical events and outcomes of a sample of exposures reported to TESS® might offer substantial insights into adverse events (AEs) that could be systematically studied with other, established pharmacoepidemiological study designs. Copyright © 2007 John Wiley & Sons, Ltd.