Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma
Elevated neutrophil to lymphocyte ratio predicts poor prognosis in nasopharyngeal carcinoma
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DOI：
10.1007/s13277-010-0124-7
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发表时间：
2011-04-01
期刊：
影响因子：
--
通讯作者：
Li, Yu-Hong
中科院分区：
文献类型：
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作者：
An, Xin;Ding, Pei-Rong;Li, Yu-Hong
据报道，中性粒细胞与淋巴细胞比率（NLR）升高与许多恶性肿瘤的生存率下降有关，而其在鼻咽癌（NPC）中的作用尚不清楚。我们回顾性分析了363例连续的、新诊断的、非播散性的、经活检证实的鼻咽癌患者。根据NLR水平比较疾病特异性生存率（DSS）、无远处转移生存率（DMFS）和局部无复发生存率（LRFS）。进行多因素分析以评估NLR的预后价值。NLR升高或未升高患者的5年DSS、DMFS和LRFS率（>或
Elevated neutrophil to lymphocyte ratio (NLR) has been reported to be associated with worse survival in many malignancies, whereas its role in nasopharyngeal carcinoma (NPC) remains unclear. We retrospectively reviewed 363 consecutively, newly diagnosed, non-disseminated, and biopsy-proven NPC patients. Disease-specific survival (DSS), distant metastasis-free survival (DMFS), and locoregional recurrence-free survival (LRFS) rates were compared according to NLR level. Multivariate analysis was performed to assess the prognostic value of NLR. The 5-year DSS, DMFS, and LRFS rates for patients with elevated or non-elevated NLR (> or