Immune responses to Helicobacter pylori colonization: mechanisms and clinical outcomes.
Immune responses to Helicobacter pylori colonization: mechanisms and clinical outcomes.
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对幽门螺杆菌定植的免疫反应：机制和临床结果。
DOI：
10.1042/cs20050232
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Perez-Perez,GuillermoI
中科院分区：
文献类型：
--
作者：
Portal-Celhay,Cynthia;Perez-Perez,GuillermoI
幽门螺杆菌使世界上一半人口的胃形成结肠，并且通常在人类宿主的胃粘膜中持续数十年或终生。虽然大多数。pylori阳性者无症状，H.幽门螺杆菌与消化性溃疡、胃腺癌和胃淋巴瘤的发生风险增加有关。对感染的持续性胃炎症和免疫反应的发展似乎是疾病发展的关键。在与人类长期共存的过程中，H。幽门螺杆菌已经进化出复杂的策略来维持胃上皮的轻度炎症，同时限制免疫效应物活性的程度。本文就H.幽门螺杆菌感染和细菌逃避它们的机制被认为是。了解细菌的定殖、持久性和毒力因子的机制以及宿主的先天性和适应性免疫应答对于开发预防H的发展的新策略至关重要。幽门引起的胃十二指肠疾病。
Helicobacter pyloricolonizes the stomachs of half of the world's population and usually persists in the gastric mucosa of human hosts for decades or life. Although mostH. pylori-positive people are asymptomatic, the presence ofH. pyloriis associated with increased risk for the development of peptic ulcer disease, gastric adenocarcinoma and gastric lymphoma. The development of a sustained gastric inflammatory and immune response to infection appears to be pivotal for the development of disease. During its long co-existence with humans,H. pylorihas evolved complex strategies to maintain a mild inflammation of the gastric epithelium while limiting the extent of immune effector activity. In this review, the nature of the host immune response toH. pyloriinfection and the mechanism employed by the bacterium to evade them is considered. Understanding the mechanisms of colonization, persistence and virulence factors of the bacterium as well as the innate and adaptive immune responses of the host are critically important for the development of new strategies to prevent the development ofH. pylori-induced gastroduodenal disease.