Antimicrobial resistance of Actinobacillus pleuropneumoniae isolated from swine
Antimicrobial resistance of Actinobacillus pleuropneumoniae isolated from swine
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DOI：
10.1016/j.vetmic.2011.10.022
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发表时间：
2012-04-23
影响因子：
3.3
通讯作者：
Intorre, Luigi
中科院分区：
文献类型：
--
作者：
Vanni, Michele;Merenda, Marianna;Intorre, Luigi
本回顾性研究的目的是评价1994年至2009年从意大利猪分离的胸膜肺炎放线杆菌的耐药率和耐药趋势。共992个A。在纸片扩散法中测试胸膜肺炎分离物对一组抗微生物剂的敏感性。对7种药物（阿莫西林、阿莫西林/克拉维酸、氨苄西林、头孢喹肟、复方新诺明、青霉素G和替米考星）的耐药性随时间呈显著增加趋势，而对2种药物（庆大霉素和马波沙星）的耐药性则显著下降。对其余14种抗菌药物的耐药性在研究期间没有显著变化。大多数分离株对通常对A有效的抗生素保持高度敏感性。胸膜肺炎，如氨酚类、氟喹诺酮类和头孢噻呋。然而，观察到增效磺胺类药物、四环素类和青霉素类的耐药率较高，这些药物是目前推荐用于猪胸膜肺炎治疗的抗菌剂。我们的研究结果表明继续监测A.胸膜肺炎临床分离株，以选择最合适的治疗感染和控制目前使用的抗微生物剂的耐药性的增加。(C)2011 Elsevier B. V.保留所有权利。
The aim of this retrospective study was to evaluate the antimicrobial resistance rates and the trend in resistance of Actinobacillus pleuropneumoniae isolated from pigs in Italy from 1994 to 2009. A total of 992 A. pleuropneumoniae isolates were tested for their susceptibility to a panel of antimicrobial agents in a disk diffusion method. Resistance to 7 drugs (amoxicillin, amoxicillin/clavulanic acid, ampicillin, cefquinome, cotrimoxazole, penicillin G and tilmicosin) showed a significant increasing trend over the time, while for 2 drugs (gentamycin and marbofloxacin) a significant decrease was observed. Resistance to the remaining 14 antimicrobial agents tested did not change significantly over the study period. Most of the isolates retained high susceptibility to antimicrobials usually effective against A. pleuropneumoniae such as amphenicols, fluoroquinolones and ceftiofur. However, high rates of resistance were observed for potentiated sulfa drugs, tetracyclines and penicillins which are currently recommended antimicrobials for pig pleuropneumonia therapy. Our results suggest the importance of continued monitoring of A. pleuropneumoniae clinical isolates in order to choose the most appropriate treatment of infections and to control the increase of resistance to currently used antimicrobials. (C) 2011 Elsevier B.V. All rights reserved.