Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.
Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.
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DOI：
10.1016/b978-0-12-800267-4.00006-7
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发表时间：
2014
影响因子：
--
通讯作者：
Stevens, Richard L.
中科院分区：
文献类型：
--
作者：
Douaiher, Jeffrey;Succar, Julien;Lancerotto, Luca;Gurish, Michael F.;Orgill, Dennis P.;Hamilton, Matthew J.;Krilis, Steven A.;Stevens, Richard L.
肥大细胞（MC）是血液凝固和先天性和获得性免疫的积极参与者。本文综述了小鼠和人类MCs的发展，以及它们的颗粒丝氨酸蛋白酶参与炎症和结缔组织重塑，发生在受伤的皮肤和其他器官愈合过程的不同阶段。累积的数据表明，MC，其胰蛋白酶，和他们的糜酶在组织修复中发挥重要作用。虽然MC最初促进愈合，但如果长期刺激它们或同时激活太多MC，它们可能是有害的。MC及其颗粒丝氨酸蛋白酶促进瘢痕疙瘩和增生性瘢痕形成的可能性使其成为损伤皮肤修复中治疗干预的潜在靶点。
Mast cells (MCs) are active participants in blood coagulation and innate and acquired immunity. This review focuses on the development of mouse and human MCs, as well as the involvement of their granule serine proteases in inflammation and the connective tissue remodeling that occurs during the different phases of the healing process of wounded skin and other organs. The accumulated data suggest that MCs, their tryptases, and their chymases play important roles in tissue repair. While MCs initially promote healing, they can be detrimental if they are chronically stimulated or if too many MCs become activated at the same time. The possibility that MCs and their granule serine proteases contribute to the formation of keloid and hypertrophic scars makes them potential targets for therapeutic intervention in the repair of damaged skin.