Mapping Choroidal and Retinal Thickness Variation in Type 2 Diabetes using Three-Dimensional 1060-nm Optical Coherence Tomography
Mapping Choroidal and Retinal Thickness Variation in Type 2 Diabetes using Three-Dimensional 1060-nm Optical Coherence Tomography
复制标题
DOI：
10.1167/iovs.10-6875
复制
发表时间：
2011-07-01
影响因子：
4.4
通讯作者：
Sheen, Nik J. L.
中科院分区：
文献类型：
--
作者：
Esmaeelpour, Marieh;Povazay, Boris;Sheen, Nik J. L.
目的.采用三维1060 nm光学相干断层扫描（3D-1060 nm-OCT）对健康受试者和糖尿病黄斑病变患者的脉络膜（ChT）和视网膜厚度（RT）进行测量。42名糖尿病受试者的63只眼睛（41-82岁; 11名女性），根据使用早期治疗糖尿病视网膜病变研究定义的自定义方案分组，用于中心凹1个椎间盘直径内的病理学（无病理[NDR]、微动脉瘤[M1]、渗出液[M2]，临床显著的黄斑水肿[CSME]）和来自16名健康年龄匹配受试者（38-79岁; 11名女性）的16只眼睛通过在36 × 36视场上进行的3D-1060 nm-OCT成像。记录眼轴长度、45张眼底照片、体重指数、血糖和血压测量值。ChT在中心凹下的位置和RPE和脉络膜-巩膜界面之间的ChT地图生成和统计分析。RT图显示NDR组变薄，但随着颞区和中央区黄斑病变的加重，厚度增加（非配对t检验; P < 0.05）。与健康眼相比，所有糖尿病患者的ChT图显示中心和下部变薄（非配对t检验; P < 0.001）。中心凹下ChT健康眼的角膜厚度（平均值+/- SD）为327 +/- 74 μ m，显著厚于所有糖尿病组（NDR为214 +/- 55 μ m，M1为208 +/- 49 μ m，M2为205 +/- 54 μ m，CSME为211 +/- 76 μ m（ANOVA P <0.001; Tukey P < 0.001）。3D-1060 nm-OCT显示，无论疾病分期如何，所有2型糖尿病患者的中央脉络膜都较薄。脉络膜变薄可能超过可能的脉络膜毛细血管萎缩的程度。与几个位置的病理厚度变化的常规评估相反，厚度图允许在受影响区域的范围内调查脉络膜。（Invest Ophthalmol维斯科学。2011; 52：5311-5316）DOI：10.1167/iovs.10-6875
PURPOSE. To map choroidal (ChT) and retinal thickness (RT) in healthy subjects and patients with diabetes with and without maculopathy using three dimensional 1060-nm optical coherence tomography (3D-1060nm-OCT).METHODS. Sixty-three eyes from 42 diabetic subjects (41-82 years of age; 11 females) grouped according to a custom scheme using Early Treatment Diabetic Retinopathy Study definitions for pathology within 1 disc-diameter of fovea (without pathology [NDR], microaneurysms [M1], exudates [M2], clinically significant macular edema [CSME]) and 16 eyes from 16 healthy age matched subjects (38-79 years of age; 11 females) were imaged by 3D-1060nm-OCT performed over a 36 X 36 field of view. Axial length, 45 fundus photographs, body mass index, plasma glucose, and blood pressure measurements were recorded. The ChT at the subfoveal location and ChT maps between RPE and the choroidal-scleral interface were generated and statistically analyzed.RESULTS. RT maps show thinning in the NDR group but an increase in thickness with increasing maculopathy in the temporal and central regions (unpaired t-test; P < 0.05). ChT mapping of all diabetic patients revealed central and inferior thinning compared to healthy eyes (unpaired t-test; P < 0.001). Subfoveal ChT (mean +/- SD) for healthy eyes was 327 +/- 74 mu m, which was significantly thicker than all diabetic groups (214 +/- 55 mu m for NDR, 208 +/- 49 mu m for M1, 205 +/- 54 mu m for M2, and 211 +/- 76 mu m for CSME (ANOVA P < 0.001; Tukey P < 0.001).CONCLUSIONS. 3D-1060nm-OCT has shown that the central choroid is thinner in all type 2 diabetic eyes regardless of disease stage. The choroidal thinning may exceed the magnitude of possible choriocapillaris atrophy. In contrast to the conventional assessment of pathologic thickness change in several locations, thickness maps allow investigation of the choroid over the extent of affected areas. (Invest Ophthalmol Vis Sci. 2011; 52:5311-5316) DOI: 10.1167/iovs.10-6875