Retention of protein complex membership by ancient duplicated gene products in budding yeast
Retention of protein complex membership by ancient duplicated gene products in budding yeast
复制标题
DOI：
10.1016/j.tig.2007.03.012
复制
发表时间：
2007-06-01
影响因子：
11.4
通讯作者：
Emili, Andrew
中科院分区：
文献类型：
--
作者：
Musso, Gabriel;Zhang, Zhaolei;Emili, Andrew
为了研究基因重复的功能差异，我们研究了酵母中由古老的全基因组重复引起的相似物复合体中的蛋白质-蛋白质相互作用和共存。引人注目的是，一半的被调查的平行对被发现在蛋白质复合物中共聚集，并且比非共聚集的平行对更保守和高表达；然而，它们不一致的表达模式和保存率表明亚功能化相似物的不同调控。这些结果突出了蛋白质复合体成员在研究基因重复之间的功能差异方面的价值。
To investigate functional divergence of gene duplicates, we examined the protein-protein interactions and coexistence in complexes of paralogs resulting from an ancient whole-genome duplication in yeast. Strikingly, half the surveyed paralog pairs were found to be co-clustered in protein complexes, and were more conserved and highly expressed than non-co-clustered paralogs; however, their discordant expression patterns and conservation rates indicate differential regulation of subfunctionalized paralogs. These results highlight the value of protein complex membership in studying functional divergence among gene duplicates.