Serological characterization of HTLV-III infection in AIDS and related disorders.
Serological characterization of HTLV-III infection in AIDS and related disorders.
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艾滋病和相关疾病中 HTLV-III 感染的血清学特征。
DOI：
10.1093/infdis/153.4.736
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
S. Landesman
中科院分区：
文献类型：
--
作者：
J. Groopman;F. W. Chen;J. Hope;J. Andrews;R. Swift;C. Benton;J. Sullivan;P. Volberding;D. Sites;S. Landesman
目前对献血者和其他人暴露于人类T细胞嗜淋巴细胞病毒III型（HTLV-III）（获得性免疫缺陷综合征（AIDS）的病原体）的测试工作是基于对病毒抗原的血清抗体的测量。我们使用ELISA和免疫印迹技术研究了767例艾滋病或艾滋病相关复合体（ARC）或无症状艾滋病高危人群血清中HTLV-III相关抗原抗体的存在。在280份来自艾滋病和ARC受试者的样本中，99%为ELISA反应，96%为免疫印迹反应。超过96%的血清学阳性受试者表现出p24核心抗原抗体，而只有88%的人有gp 41蛋白酶相关糖蛋白抗体。与之前的报道相反，免疫印迹试验中的短孵育时间未能检测到通过过夜孵育检测到的低滴度或低亲和力抗体。有症状与无症状血清阳性个体的HTLV-III相关抗原抗体模式无明显差异。
Current efforts to test blood donors and other persons for exposure to the human T cell lymphotropic virus type III (HTLV-III), the etiologic agent of the acquired immunodeficiency syndrome (AIDS), are based on the measurement of serum antibodies to viral antigens. We studied presence of serum antibodies to HTLV-III-related antigens from 767 individuals with AIDS or AIDS-related complex (ARC) or asymptomatic persons at risk for AIDS by using ELISA and immunoblot techniques. Of the 280 specimens from AIDS and ARC subjects that were tested, 99% were ELISA reactive and 96% were immunoblot reactive. Greater than 96% of the seropositive subjects manifested antibodies to the p24 core antigen, whereas only 88% had antibodies to the gp41 envelope-related glycoprotein. Contrary to previous reports, a short incubation time in the immunoblot assay failed to detect low-titer or low-affinity antibodies that were detected by overnight incubation. There was no apparent difference in pattern of antibodies to HTLV-III-related antigens in symptomatic vs. asymptomatic seropositive individuals.
输血相关艾滋病病例的病毒学研究。
DOI：
10.1056/nejm198411293112206
发表时间：
1984
期刊：
The New England journal of medicine
影响因子：
--
作者：
Groopman,JE;Salahuddin,SZ;Sarngadharan,MG;Mullins,JI;Sullivan,JL;Mulder,C;O'Hara,CJ;Cheeseman,SH;Haverkos,H;Forgacs,P
通讯作者：
Forgacs,P
人类 T 细胞白血病病毒 III 型明显传播给患有获得性免疫缺陷综合征的异性恋女性。
影响因子：
39.2
作者：
Groopman,JE;Sarngadharan,MG;Salahuddin,SZ;Buxbaum,R;Huberman,MS;Kinniburgh,J;Sliski,A;McLane,MF;Essex,M;Gallo,RC
通讯作者：
Gallo,RC