Intake of vegetables rich in carotenoids and risk of coronary heart disease in men: The Physicians' Health Study
Intake of vegetables rich in carotenoids and risk of coronary heart disease in men: The Physicians' Health Study
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DOI：
10.1093/ije/30.1.130
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发表时间：
2001-02-01
影响因子：
7.7
通讯作者：
Manson, JE
中科院分区：
文献类型：
--
作者：
Liu, SM;Lee, IM;Manson, JE
背景以前的饮食和心脏病（CHD）的研究集中在营养素的摄入，而不是整个食物。由于膳食纤维、叶酸和抗氧化剂可能对冠心病有保护作用，因此建议增加蔬菜的摄入量。然而，由于蔬菜的化学和物理复杂性，如果作为整个食物食用，个别营养素的效果可能会有所不同。此外，鲜为人知的是，蔬菜摄入量和CHD的风险之间的直接关联。方法我们前瞻性地评估了蔬菜摄入量和CHD的风险之间的关系，在医生的健康研究，阿司匹林和β-胡萝卜素的随机试验22 071美国男性医生年龄在40-84岁，1982年。在这项分析中，我们纳入了15220名基线时没有心脏病、中风或癌症的男性，他们提供了基线时蔬菜摄入量的信息，并在第2年、第4年和第6年使用简单的半定量食物频率问卷进行随访，其中包括8种蔬菜。我们确认了1148例冠心病病例结果在对年龄、随机治疗、体重指数（BMI）、吸烟、饮酒、体力活动、糖尿病史、高血压史、高胆固醇史等因素进行校正后，和使用多种维生素，每天食用至少2.5份蔬菜的男性患CHI的相对风险（RR）为0.77（95%CI：0.60-0.98），与最低类别的男性相比（
Background Previous studies of diet and corollary heart disease (CHD) have focused on intake of nutrients rather than whole foods. Because of the findings that dietary fibre, folate and antioxidants may be protective for CHD, increased intake of vegetables has been recommended. However, due to the chemical and physical complexity of vegetables, the effects of individual nutrients may differ if eaten as whole foods. Moreover, little is known about the direct association between vegetable intake and risk of CHD.Methods We prospectively evaluated the relation between vegetable intake and CHD risk in the Physicians' Health Study, a randomized trial of aspirin and beta-carotene among 22 071 US male physicians aged 40-84 years in 1982. In this analysis, we included 15 220 men without heart disease, stroke or cancer at baseline who provided information on their vegetable intake at baseline, and in the 2nd, 4th and 6th years of follow-up using a simple semiquantitative food frequency questionnaire including eight vegetables. We confirmed 1148 incident cases of CHD (387 incident cases of myocardial infarction and 761 incident cases of coronary artery bypass grafting or percutaneous transluminadl coronary angioplasty) during 12 pears of follow-up.Results After adjusting for age, randomized treatment, body mass index (BMI), smoking, alcohol intake, physical activity, history of diabetes, history of hypertension, history of high cholesterol, and use of multivitamins, men who consumed at least 2.5 servings/day of vegetables had a relative risk (RR) of 0.77 (95% CI : 0.60-0.98) for CHI), compared with men in the lowest category (