Selective Anion Sensing in High Salt Water via a Remote Indicator Displacement Assay
Selective Anion Sensing in High Salt Water via a Remote Indicator Displacement Assay
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通过远程指示剂位移测定选择性检测高盐水中的阴离子
DOI：
10.1039/d3cc01974h
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发表时间：
2023
影响因子：
4.9
通讯作者：
Hooley, Richard James
中科院分区：
文献类型：
--
作者：
Hickey, Briana L;Raz, Alexie Andrea;Chen, Junyi;Moreno, Jose L.;Hartman, Joshua D;Zhong, Wenwan;Hooley, Richard James
在纯水溶液中，下缘具有阳离子功能的水溶性深空腔体可以选择性地结合碘离子阴离子。通过将这种下边缘识别与结合在宿主腔中的指示染料配对，阴离子的光学传感成为可能。对碘化物的选择性足够高，在摩尔氯化物存在的情况下可以检测到微量的碘化物。碘化物在“远端”下边缘的结合引起宿主的构象变化，将结合的染料从腔中移出并影响荧光响应。该传感具有灵敏度高、选择性好、工作环境复杂等特点，对生物相关介质的光学阴离子检测具有重要意义。
Water-soluble deep cavitands with cationic functions at the lower rim can selectively bind iodide anions in purely aqueous solution. By pairing this lower rim recognition with an indicator dye that is bound in the host cavity, optical sensing of anions is possible. The selectivity for iodide is high enough that micromolar concentrations of iodide can be detected in the presence of molar chloride. Iodide binding at the “remote” lower rim causes a conformational change in the host, displacing the bound dye from the cavity and effecting a fluorescence response. The sensing is sensitive, selective, and works in complex environments, so will be important for optical anion detection in biorelevant media.