A two-locus neutrality test: applications to humans, E. coli and lodgepole pine.
A two-locus neutrality test: applications to humans, E. coli and lodgepole pine.
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双位点中性测试：应用于人类、大肠杆菌和黑松。
DOI：
10.1093/genetics/112.1.135
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发表时间：
1986
期刊：
影响因子：
3.3
通讯作者：
Thomson,G
中科院分区：
文献类型：
--
作者：
Hedrick,PW;Thomson,G
The expected disequilibrium between two loci withkalleles at one locus andlalleles at the other is given for a sample of sizendrawn from a population under neutrality equilibrium. Three different measures of disequilibrium with 95% intervals are tabulated for combinations ofn, k, land 4Nc, whereNis the effective population size andcis the amount of recombination between the loci. The extent and pattern of disequilibrium are strongly dependent upon 4Ncand are somewhat dependent onn, kandl. The 95% intervals are large, particularly for low numbers of alleles and low values of 4Nc. As examples, observed disequilibrium from histocompatibility loci in humans (HLA) and electrophoretic data inE. coliand lodgepole pine were compared to these theoretical values. Using information about recombination rates, the HLA data showed more disequilibrium than neutrality expectations, whereas electrophoretic data fromE. coliand lodgepole pine had somewhat less disequilibrium than neutrality expectations.
