Cannabis withdrawal in the United States: Results from NESARC
Cannabis withdrawal in the United States: Results from NESARC
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DOI：
10.4088/jcp.v69n0902
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发表时间：
2008-09-01
影响因子：
5.3
通讯作者：
Grant, Bridget E.
中科院分区：
文献类型：
--
作者：
Hasin, Deborah S.;Keyes, Katherine M.;Grant, Bridget E.
目的：虽然大麻是最广泛滥用的非法药物，但对大麻戒断的流行率及其因素结构、临床有效性和一般人群中的精神相关性知之甚少。方法：在2001-2002年，对酒精和相关疾病的国家流行病学调查参与者进行了评估，包括物质史，DSM-IV轴I和11种疾病，以及停止使用后的戒断症状。其中，2613人经常使用大麻（>= 3次/周），和一个“大麻只”子集（N = 1119）从来没有暴饮暴食或使用其他药物3次/week.Results：在全样本和子集，44.3%（SE = 1.19）和44.2%（SE = 1.75），分别经历！2大麻戒断症状，而34.4%（SE = 1.21）和34.1%（SE = 1.76），分别经历！3症状。症状形成2个因素，一个以虚弱、嗜睡和精神发育迟滞为特征，另一个以焦虑、不安、抑郁和失眠为特征。这两种症状类型都与显著的痛苦/损害（p < .01），缓解/避免大麻戒断症状的物质使用（p < .01）和大麻使用量（仅大麻使用者中p < .05）相关。恐慌（p < .01）和个性（p
Objective: Although cannabis is the most widely abused illicit drug, little is known about the prevalence of cannabis withdrawal and its factor structure, clinical validity, and psychiatric correlates in the general population.Method: National Epidemiologic Survey on Alcohol and Related Conditions participants were assessed, in 2001-2002, with structured in-person interviews covering substance history, DSM-IV Axis I and 11 disorders, and withdrawal symptoms after cessation of use. Of these, 2613 had been frequent cannabis users (>= 3 times/week), and a "cannabis-only" subset (N = 1119) never binge-drank or used other drugs 3 times/week.Results: In the full sample and subset, 44.3% (SE = 1.19) and 44.2% (SE = 1.75), respectively, experienced ! 2 cannabis withdrawal symptoms, while 34.4% (SE = 1.21) and 34.1% (SE = 1.76), respectively, experienced ! 3 symptoms. The symptoms formed 2 factors, one characterized by weakness, hypersomnia, and psychomotor retardation and the second by anxiety, restlessness, depression, and insomnia. Both symptom types were associated with significant distress/impairment (p < .01), substance use to relieve/avoid cannabis withdrawal symptoms (p < .01), and quantity of cannabis use (among the cannabis-only users p < .05). Panic (p < .01) and personality (p