Continuous stimulation of transected distal nerves fails to prolong action potential propagation.
Continuous stimulation of transected distal nerves fails to prolong action potential propagation.
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连续刺激横断的远端神经无法延长动作电位的传播。
DOI：
10.1097/01.blo.0000203481.11797.0f
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Stewart,Mark
中科院分区：
文献类型：
--
作者：
O'Gara,Tadhg;Urban,William;Polishchuk,Daniil;Pierre-Louis,Alain;Stewart,Mark
被切断的神经的远端部分的沃勒变性被认为是不可逆的。变性的一个可能原因是远端切断的神经缺乏轴突刺激。我们假设远端神经残端的更大刺激率将延长动作电位传播失败的时间，并且未切割的神经不会被植入的神经刺激器损坏。我们还假设，从坐骨神经的身体测量的动作电位将显示类似的反应，在坐骨神经的分支支配的肌肉中测量的运动诱发电位。将神经刺激器植入大鼠坐骨神经远端，记录运动诱发电位。三组分别以1 Hz（每秒一次）、0.1 Hz（每10秒一次）和0.01 Hz（每100秒一次）刺激。运动诱发电位在神经切断后逐渐下降，与0.01 Hz刺激（36.75小时±83分钟）相比，1 Hz（26.8小时±108分钟）和0.1 Hz（22小时±66分钟）下的下降更快。植入的神经刺激器不会损伤完整的轴突。直接从神经记录的动作电位相当于运动诱发电位。断离的神经中运动诱发电位传递的失败被远端残端的更大速率的连续刺激加速。
Wallerian degeneration of the distal portion of a cut nerve is considered irreversible. A possible reason for degeneration is lack of axon stimulation in the distal, cut nerves. We hypothesized greater rates of stimulation of distal nerve stumps would prolong time to action potential propagation failure, and uncut nerves would not be damaged by implanted nerve stimulators. We also hypothesized that action potentials measured from the body of the sciatic nerve would show similar response as motor-evoked potentials measured in the muscles innervated by branches of the sciatic nerve. We implanted a nerve stimulator onto distal cut sciatic nerves of rats and recorded motor-evoked potentials. Three groups were stimulated at 1 Hz (once per second), 0.1 Hz (once per 10 seconds), and 0.01 Hz (once per 100 seconds) respectively. Motor-evoked potentials progressively declined after nerve transection, failing faster at 1 Hz (26.8 hours±108 minutes) and 0.1 Hz (22 hours±66 minutes) compared with stimulation at 0.01 Hz (36.75 hours±83 minutes). Intact axons were not damaged by implanted nerve stimulators. Action potentials recorded directly from nerves were equivalent to motor-evoked potentials. Failure of motor-evoked potential transmission in a transected nerve is accelerated by a greater rate of continuous stimulation of the distal stump.