Bacterial immunotherapy of gastrointestinal tumors.
Bacterial immunotherapy of gastrointestinal tumors.
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DOI：
10.1007/s00423-011-0892-6
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发表时间：
2012-04
影响因子：
2.3
通讯作者：
Klar, Ernst
中科院分区：
文献类型：
--
作者：
Linnebacher, Michael;Maletzki, Claudia;Klier, Ulrike;Klar, Ernst
使用细菌的癌症免疫疗法可以追溯到150多年前。对免疫系统如何干扰肿瘤微环境的更深入理解导致了细菌或其相关产物在免疫学概念中的重新出现。本文综述了近年来溶菌疗法的研究进展，强调了细菌、免疫细胞和肿瘤细胞之间的特异性相互作用，以打破肿瘤诱导的耐受。过去几十年的实验研究表明，细菌对肿瘤生长有有利的影响，但也有不利的影响。慢性感染和肿瘤发病率之间有很强的相关性。然而，急性细菌感染对肿瘤生长有有利的影响，通常有助于完全缓解。肿瘤消退通常可归因于直接肿瘤细胞杀伤（通过凋亡和/或坏死，取决于所应用的细菌）和间接免疫刺激。这包括（I）消除免疫抑制性免疫细胞（即肿瘤相关巨噬细胞、骨髓源性抑制细胞和调节性T细胞），（II）抑制Th 2介导的细胞因子分泌（TGFα、IL 10），（III）提供促炎性微环境（肿瘤浸润性中性粒细胞）和（IV）支持细胞毒性T细胞流入肿瘤。这最终迫使免疫记忆的发展，并可能提供长期的抗癌保护。使用细菌的免疫疗法仍然是一把双刃剑。过去几年的经验大大有助于细菌及其定义的组分何时可能被整合到免疫学概念中。目前正在尝试将这种方法推广到诊所。
Cancer immunotherapy using bacteria dates back over 150 years. The deeper understanding on how the immune system interferes with the tumor microenvironment has led to the re-emergence of bacteria or their related products in immunotherapeutic concepts. In this review, we discuss recent approaches on experimental bacteriolytic therapy, emphasizing the specific interplay between bacteria, immune cells and tumor cells to break the tumor-induced tolerance. Experimental research during the last decades demonstrated beneficial but also adverse influence of bacteria on tumor growth. There is a strong correlation between chronic infections and tumor incidence. However, acute bacterial infections have favourable effects on tumor growth often contributing to complete remission. Tumor regression is usually attributable to both direct tumor cell killing (via apoptosis and/or necrosis, depending on the applied bacteria) and indirect immune stimulation. This includes (I) elimination of immunosuppressive immune cells (i.e. tumor-associated macrophages, myeloid-derived suppressor, and regulatory T cells), (II) suppression of Th2-directed cytokine secretion (TGFα, IL10), (III) providing a pro-inflammatory micro-milieu (tumor infiltrating neutrophils) and (IV) supporting the influx of cytotoxic T cells into tumors. This finally forces the development of an immunological memory and may provide long-term protection against cancer. Immunotherapy using bacteria is still a double-edged sword. Experiences from the last years have substantially contributed to when bacteria and defined components thereof might be integrated into immunotherapeutic concepts. Attempts in transferring this approach into the clinics are on their way.
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影响因子：
4
作者：
Hayashi, Katsuhiro;Zhao, Ming;Yamauchi, Kensuke;Yamamoto, Norio;Tsuchiya, Hiroyuki;Tomita, Katsuro;Hoffman, Robert M.
通讯作者：
Hoffman, Robert M.
影响因子：
6.4
作者：
Goldmann, O;Chhatwal, GS;Medina, E
通讯作者：
Medina, E
影响因子：
11.2
作者：
Huang, B;Zhao, J;Xiong, HB
通讯作者：
Xiong, HB
影响因子：
3.8
作者：
Diaz, LA;Cheong, I;Huso, DL
通讯作者：
Huso, DL
DOI：
10.1073/pnas.0406242101
发表时间：
2004-10-19
影响因子：
11.1
作者：
Agrawal, N;Bettegowda, C;Vogelstein, B
通讯作者：
Vogelstein, B