Pulsatile blood flow in the entire coronary arterial tree: theory and experiment
Pulsatile blood flow in the entire coronary arterial tree: theory and experiment
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DOI：
10.1152/ajpheart.00200.2006
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发表时间：
2006-09-01
影响因子：
4.8
通讯作者：
Kassab, Ghassan S.
中科院分区：
文献类型：
--
作者：
Huo, Yunlong;Kassab, Ghassan S.
冠状动脉循环的脉动性可以基于所测量的冠状动脉脉管系统的分支模式、血管几何形状和材料特性来准确地模拟。Womersley型的数学模型的开发，以分析脉动血流在血管张力的情况下，在整个冠状动脉树的基础上，先前测量的形态测量数据的冠状动脉。该模型结合了本构方程的压力和横截面积的关系，根据我们以前的实验数据。该公式能够预测整个冠状动脉树的阻抗、压力分布和脉动流分布。该模型通过在6个舒张期阻滞、血管舒张的猪心中的实验测量进行验证。理论和实验之间的一致性是极好的。此外，在低频脉冲波的结果与以前发表的稳态模型吻合得很好。最后，可以看到流动的相位角沿着主冠状动脉的主干和朝向毛细血管的主要分支沿着减小。这项研究代表了第一个，最广泛的验证分析Womersley型脉搏波传输在整个冠状动脉树下降到第一段毛细血管。本模型将用于定量测试脉动流条件下冠状动脉循环中的各种假设。
The pulsatility of coronary circulation can be accurately simulated on the basis of the measured branching pattern, vascular geometry, and material properties of the coronary vasculature. A Womersley-type mathematical model is developed to analyze pulsatile blood flow in diastole in the absence of vessel tone in the entire coronary arterial tree on the basis of previously measured morphometric data. The model incorporates a constitutive equation of pressure and cross-section area relation based on our previous experimental data. The formulation enables the prediction of the impedance, the pressure distribution, and the pulsatile flow distribution throughout the entire coronary arterial tree. The model is validated by experimental measurements in six diastolic arrested, vasodilated porcine hearts. The agreement between theory and experiment is excellent. Furthermore, the present pulse wave results at low frequency agree very well with previously published steady-state model. Finally, the phase angle of flow is seen to decrease along the trunk of the major coronary artery and primary branches toward the capillary vessels. This study represents the first, most extensive validated analysis of Womersley-type pulse wave transmission in the entire coronary arterial tree down to the first segment of capillaries. The present model will serve to quantitatively test various hypotheses in the coronary circulation under pulsatile flow conditions.