ASSOCIATIONS BETWEEN BODY MASS INDEX AND SERUM URIC ACID LEVELS IN A JAPANESE POPULATION WERE SIGNIFICANTLY MODIFIED BY LRP2 rs2544390
ASSOCIATIONS BETWEEN BODY MASS INDEX AND SERUM URIC ACID LEVELS IN A JAPANESE POPULATION WERE SIGNIFICANTLY MODIFIED BY LRP2 rs2544390
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LRP2 rs2544390 显着改变了日本人群的体重指数和血清尿酸水平之间的关联
DOI：
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发表时间：
2014
影响因子：
0.9
通讯作者：
N. Hamajima
中科院分区：
文献类型：
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作者：
S. Suma;M. Naito;R. Okada;S. Kawai;G. Yin;Emi Morita;K. Wakai;H. Matsuo;N. Hamajima
全基因组关联研究确定了日本人群中LRP2多态性rs2544390与血清尿酸（SUA）水平之间的关联。我们之前对LRP2 rs2544390多态性的研究发现了SUA与饮酒之间的相互作用。在这里，我们使用相同的数据集调查了与身体质量指数（BMI）的相互作用。受试者为3742名健康体检者（男性2544名，女性1198名），年龄35-69岁。选择SLC22A12 258WW基因型、SLC2A9 rs11722228 C等位基因、ABCG2 126QQ基因型和141Q等位基因进行分析，以消除这些遗传性状的强影响。在男性中，高尿酸血症（SUA≥7 mg/dL和/或正在服药）BMI≥25.0相对于BMI <18.5的比值比，CC为6.58(95%可信区间[CI]， 0.84-51.32)， CT为10.08 (2.38-42.83)，TT为2.53（0.54-11.78）。在包括BMI（<25.0和≥25.0）、基因型（CC/CT和TT）以及BMI≥25.0与TT基因型相乘的相互作用项的模型中，相互作用为0.59 （p=0.029）。在女性中，高SUA（≥5 mg/dL和/或高尿酸血症用药）的BMI≥25.0相对于BMI <18.5的比值比，CC为6.35 (95%CI, 1.68-24.08)， CT为4.55 (1.85-11.18)，TT为5.93（1.97-17.90）。女性的交互作用项呈相反方向显著（OR=2.75, p=0.011）。因此，BMI和SUA之间的关联被该日本人群中的LRP2多态性所修饰。
ABSTRACT The genome-wide association study identified associations between the LRP2 polymorphism rs2544390 and serum uric acid (SUA) levels in a Japanese population. Our previous study on the LRP2 rs2544390 polymorphism identified an interaction between SUA and alcohol consumption. Here, we investigated an interaction with body mass index (BMI) using the same dataset. Subjects were 3,742 health checkup examinees (2,544 males and 1,198 females) aged 35–69 years. Those with the SLC22A12 258WW genotype, SLC2A9 rs11722228 C allele, and ABCG2 126QQ genotype and 141Q allele were selected for analysis to remove the strong influences of these genetic traits. In males, the odds ratio of BMI ≥25.0 relative to BMI <18.5 for hyperuricemia (SUA ≥7 mg/dL and/or under medication for hyperuricemia) was 6.58 (95% confidence interval [CI], 0.84–51.32) for CC, 10.08 (2.38–42.83) for CT, and 2.53 (0.54–11.78) for TT. The interaction was 0.59 (p=0.029) from the model including BMI (<25.0 and ≥25.0), genotype (CC/CT and TT), and the multiplicative interaction term between BMI ≥25.0 and the TT genotype. In females, the odds ratio of BMI ≥25.0 relative to BMI <18.5 for high SUA (≥5 mg/dL and/or under medication for hyperuricemia) was 6.35 (95%CI, 1.68–24.08) for CC, 4.55 (1.85–11.18) for CT, and 5.93 (1.97–17.90) for TT. The interaction term was significant in the opposite direction for females (OR=2.75, p=0.011). The association between BMI and SUA was therefore modified by the LRP2 polymorphism in this Japanese population.
DOI：
10.1073/pnas.95.26.15665
发表时间：
1998-12-22
影响因子：
11.1
作者：
Doyle, LA;Yang, WD;Ross, DD
通讯作者：
Ross, DD