Computing Ischemic Regions in the Heart With the Bidomain Model—First Steps Towards Validation
Computing Ischemic Regions in the Heart With the Bidomain Model—First Steps Towards Validation
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使用双域模型计算心脏缺血区域——验证的第一步
DOI：
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发表时间：
2013
影响因子：
10.6
通讯作者：
P. Grøttum
中科院分区：
文献类型：
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作者：
B. F. Nielsen;O. M. Lysaker;P. Grøttum
我们研究是否有可能使用bidomain模型和体表电位图（BSPM）来计算人体心脏缺血区域的大小和位置。这将导致一个严重不适定的反问题的潜在方程。我们不使用经典的心电图逆问题，其中未知的来源是心外膜电位分布或激活序列。相反，我们采用bidomain理论，以获得一个模型，也使识别缺血区域transmartally。这种方法使得有可能区分内膜下和透壁病例，仅使用BSPM数据。主要的重点是在临床数据上测试先前发表的算法，并将结果与灌注成像拍摄的图像进行比较。对于参与本研究的4名患者，两种模式产生的结果相当相似：两种模式显示的质心和缺血区域大小之间的相对差异分别为10.8% ± 4.4%和7.1% ± 4.6%。我们还提出了一些模拟表明，该方法是强大的重要模型参数的不确定性。然而，与仅涉及合成数据的调查中观察到的情况相反，需要不平等约束才能获得合理的结果。
We investigate whether it is possible to use the bidomain model and body surface potential maps (BSPMs) to compute the size and position of ischemic regions in the human heart. This leads to a severely ill posed inverse problem for a potential equation. We do not use the classical inverse problems of electrocardiography, in which the unknown sources are the epicardial potential distribution or the activation sequence. Instead we employ the bidomain theory to obtain a model that also enables identification of ischemic regions transmurally. This approach makes it possible to distinguish between subendocardial and transmural cases, only using the BSPM data. The main focus is on testing a previously published algorithm on clinical data, and the results are compared with images taken with perfusion scintigraphy. For the four patients involved in this study, the two modalities produce results that are rather similar: The relative differences between the center of mass and the size of the ischemic regions, suggested by the two modalities, are 10.8% ± 4.4% and 7.1% ± 4.6%, respectively. We also present some simulations which indicate that the methodology is robust with respect to uncertainties in important model parameters. However, in contrast to what has been observed in investigations only involving synthetic data, inequality constraints are needed to obtain sound results.
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影响因子：
--
作者：
Y. Rudy;B. Messinger-Rapport
通讯作者：
Y. Rudy;B. Messinger-Rapport
DOI：
10.1152/ajpheart.00618.2011
发表时间：
2012-01-01
影响因子：
4.8
作者：
Han, Chengzong;Pogwizd, Steven M.;He, Bin
通讯作者：
He, Bin
影响因子：
37.8
作者：
Burnes, JE;Taccardi, B;Rudy, Y
通讯作者：
Rudy, Y
影响因子：
24
作者：
Cuculich, Phillip S.;Zhang, Junjie;Wang, Yong;Desouza, Kavit A.;Vijayakumar, Ramya;Woodard, Pamela K.;Rudy, Yoram
通讯作者：
Rudy, Yoram