Third ventricle choroid plexus function and its response to acute perturbations in plasma chemistry.
Third ventricle choroid plexus function and its response to acute perturbations in plasma chemistry.
复制标题
第三脑室脉络丛功能及其对等离子体化学急性扰动的反应。
DOI：
10.1016/0006-8993(86)90402-6
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发表时间：
1986
期刊：
影响因子：
2.9
通讯作者：
Johanson,CE
中科院分区：
文献类型：
--
作者：
Harbut,RE;Johanson,CE
通过对成年Sprague-Dawley大鼠血浆化学扰动诱导的第三脑室脉络膜丛（3VCP）上皮离子浓度变化的定量研究，探讨了3VCP在维持脑脊液电解质中的稳态作用。相对于基线水平，以及5-60分钟系统性代谢性酸中毒引起的改变，上皮细胞Na+和K+含量存在显著的区域差异（第三vs第四（4VCP）和侧脑室CP (LVCP)）。3VCP约占脉络膜组织总量的10%，其含水量、细胞外液体积和血管密度与4VCP和LVCP相当；但3VCP的特点是细胞[Na+] （68 mM）和[K+] （118 mM）的值相对较高和较低。与时间匹配的对照组相比，急性代谢性酸中毒（如NH4Cl）对3VCP的反应，即↑[K+]和↓[Na+]的影响小于4VCP，且明显小于LVCP。3个神经丛区诱导电解质变化的开始时间和持续时间在性质上相似。虽然全身性酸中毒严重改变CP电解质浓度，但不影响脑脊液[K+]和[Na+]的稳态。从分泌能力、胚胎起源和神经支配等方面讨论了3VCP的功能。总的来说，研究结果表明，介导Na+和K+跨膜分布的转运/渗透性现象在3VCP中与血- csf屏障的其他区域在数量上有所不同。
The homeostatic role of the third ventricle choroid plexus (3VCP) in the maintenance of CSF electrolytes was investigated by quantifying alterations in CP epithelial ion concentrations induced by chemical perturbations of plasma in adult Sprague-Dawley rats. Significant regional differences (third vs fourth (4VCP) and lateral ventricle CP (LVCP)) were found in epithelial content of Na+and K+, with respect to baseline levels as well as alterations caused by 5–60 min of systemic metabolic acidosis. 3VCP, which comprises ca. 10% of total choroidal tissue, has a water content, extracellular fluid volume and vascularity comparable to 4VCP and LVCP; yet 3VCP is characterized by relatively high and low values for cellular [Na+] (68 mM) and [K+] (118 mM). Compared to time-matched controls, acute metabolic acidosis (i.p. NH4Cl) effected a response, i.e. ↑ [K+] and ↓ [Na+], in 3VCP that was less than in 4VCP, and substantially smaller than in LVCP. The onset and duration of induced electrolyte changes were qualitatively similar among the 3 plexus regions. Although systemic acidosis severely altered CP electrolyte concentrations, it did not compromise CSF homeostasis of [K+] and [Na+]. The function of 3VCP is discussed in terms of secretory capacity, embryological origin, and innervation. Overall, the findings indicate that transport/permeability phenomena which mediate transmembrane distribution of Na+and K+in 3VCP differ quantitatively from other regions of the blood-CSF barrier.