Endemicity of human metapneumovirus subgenogroups A2 and B2 in Yamagata, Japan, between 2004 and 2009
Endemicity of human metapneumovirus subgenogroups A2 and B2 in Yamagata, Japan, between 2004 and 2009
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DOI：
10.1111/j.1348-0421.2010.00253.x
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发表时间：
2010-10-01
影响因子：
2.6
通讯作者：
Ahiko, Tadayuki
中科院分区：
文献类型：
--
作者：
Mizuta, Katsumi;Abiko, Chieko;Ahiko, Tadayuki
为了阐明纵向流行病学，我们从2004年至2009年日本山形县急性呼吸道感染患者中分离出280株hMPV。我们观察到hMPV的高峰期是冬季到春季（一月到五月之间），淡季是秋季（九月和十月左右）。进一步的分子分析显示，亚基因组A2（A2）菌株是最常见的分离株（151/280; 53.9%），其次是B2（108/280; 38.6%）和B1（19/280; 6.8%）。我们的研究结果表明，A2和B2已作为主要的流行类型，几乎每年，而其他亚基因组出现的频率较低。
To clarify a longitudinal epidemiology, we isolated 280 hMPV strains from patients with acute respiratory infections in Yamagata, Japan, between 2004 and 2009. We observed that the high season for hMPV was from winter to spring (between January and May) and the low season was in the fall (around September and October). A further molecular analysis revealed that subgenogroup A2 (A2) strains were the most commonly isolated (151/280; 53.9%), followed by B2 (108/280; 38.6%) and B1 (19/280; 6.8%). Our results suggested that A2 and B2 have been endemically in circulation as the major types almost every year, whereas other subgenogroups have appeared less frequently.