Lymphoma survivors have an increased long-term risk of chronic kidney disease
Lymphoma survivors have an increased long-term risk of chronic kidney disease
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DOI：
10.1080/10428194.2020.1786555
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发表时间：
2020-07-09
影响因子：
2.6
通讯作者：
Malkovska, Vera
中科院分区：
文献类型：
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作者：
Desai, Sanjal H.;Al-shbool, Ghassan;Malkovska, Vera
随着淋巴瘤生存率的提高，出现了治疗的晚期效应。在这里，我们描述了淋巴瘤幸存者长期慢性肾脏疾病（CKD）的模式。记录人口统计学、合并症、淋巴瘤组织学、治疗和结局。在诊断时、1年、2年、5年和10年记录肾小球滤过率（GFR）。记录GFR随时间的下降率和无CKD生存率。在397例患者中，中位年龄为55.3岁（18-88岁），54%为男性，60%为非洲裔美国人，42%患有高血压（HTN），15%患有DM，13%患有高尿酸血症，86%接受化疗，14%患有基线CKD。125例（31%）患者在淋巴瘤诊断后10年内发生CKD。CKD发生的概率随时间显著增加（1年时为23%，10年时为41%）。GFR下降率为4.6 mL/min/年。年龄、高血压、高尿酸血症和糖尿病（年轻患者）可预测CKD的风险。因此，淋巴瘤幸存者有相当大的慢性肾病发展的长期风险。
With improving lymphoma survival, late effects of therapy have emerged. Here, we describe pattern of long-term chronic kidney disease (CKD) in lymphoma survivors. Demographics, comorbidities, lymphoma histology, treatment, and outcome were recorded. Glomerular filtration rate (GFR) was recorded at diagnosis, 1, 2, 5, and 10 years. Rate of GFR decline with time and CKD-free survival were recorded. In 397 patients, median age was 55.3 (18-88), 54% were male, 60% were African Americans, 42% had hypertension (HTN), 15% had DM, 13% had hyperuricemia, 86% received chemotherapy, and 14% had baseline CKD. Total 125 (31%) patients developed CKD in 10 years after lymphoma diagnosis. Probability of CKD development increased significantly with time (23% at 1 year to 41% at 10 years). Rate of GFR decline was 4.6 mL/min/per year. Age, HTN, hyperuricemia, and DM (in young patients) predicted risk of CKD. Thus, lymphoma survivors are at substantial long-term risk of CKD development.