At the crossroads of oxygen and iron sensing: hepcidin control of HIF-2α.
At the crossroads of oxygen and iron sensing: hepcidin control of HIF-2α.
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在氧和铁传感的十字路口：铁调素控制 HIF-2α。
DOI：
10.1172/jci125509
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Lee,FrankS
中科院分区：
文献类型：
--
作者：
Lee,FrankS
铁调素是铁代谢的主要调节剂。它在铁跨十二指肠上皮转运的调节中发挥关键作用，而铁转运又依赖于氧调节转录因子缺氧诱导因子 2α (HIF-2α)。在本期的 JCI 中，Schwartz 及其同事表明，十二指肠 HIF-2α 本身受铁调素调节，从而表明该转录因子不仅受氧调节，还受铁调节。这项工作表明，肝脏铁调素和肠道 HIF-2α 之间的串扰在铁超载、全身性缺铁和贫血期间发挥着重要作用。
Hepcidin is the master regulator of iron metabolism. It plays a key role in the regulation of iron transport across the duodenal epithelium, which in turn is dependent on the oxygen-regulated transcription factor hypoxia-inducible factor 2α (HIF-2α). In this issue of theJCI, Schwartz and colleagues show that duodenal HIF-2α is itself regulated by hepcidin, thereby indicating that this transcription factor is not only regulated by oxygen, but also by iron. This work indicates that the crosstalk between liver hepcidin and intestinal HIF-2α plays an important role during iron overload, systemic iron deficiency, and anemia.