Mitochondrial targeting of selective electron scavengers: Synthesis and biological analysis of hemigramicidin-TEMPO conjugates
Mitochondrial targeting of selective electron scavengers: Synthesis and biological analysis of hemigramicidin-TEMPO conjugates
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DOI：
10.1021/ja053679l
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发表时间：
2005-09-14
影响因子：
15
通讯作者：
Kagan, VE
中科院分区：
文献类型：
--
作者：
Wipf, P;Xiao, JB;Kagan, VE
人工合成的半杀菌素S-肽TEMPO结合物有效地输送到细胞和线粒体中，在那里它们作为电子清除剂，对细胞凋亡起到保护作用。我们的传递方法是基于使用特定的结构信号特征，细胞可识别为线粒体靶向序列，并提供相当大的治疗抗凋亡潜力。
Synthetic hemigramicidin S-peptidyl TEMPO conjugates are effectively delivered into cells and mitochondria, where they act as electron scavengers and exert protection against apoptosis. Our delivery approach is based on the use of specific structural signaling features recognizable by cells as mitochondria targeting sequences and offers considerable therapeutic anti-apoptotic potential.