Acute and long-term ventilatory effects of hyperoxia in the adult sleep apnea syndrome.
Acute and long-term ventilatory effects of hyperoxia in the adult sleep apnea syndrome.
复制标题
高氧对成人睡眠呼吸暂停综合征的急性和长期通气作用。
DOI：
10.1164/arrd.1982.125.2.175
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
B. Pennock
中科院分区：
文献类型：
--
作者：
R. Martin;M. Sanders;B. A. Gray;B. Pennock
研究人员对八名患有睡眠呼吸暂停的成年患者进行了研究，以评估高氧血症对通气和心脏的急性影响。随后，5 名患者使用低流量夜间吸氧 30 至 90 天。急性研究的结果表明，在 30 分钟的研究期间，从室内空气到吸氧期间，呼吸暂停总数和呼吸暂停时间百分比（呼吸暂停持续时间除以睡眠时间）显着下降（分别为 207 至 68，p 小于 0.05；41.1 +/- 18.3% SD 至 20.5 +/- 14.4%，p 小于 0.05）。此外，补充氧气可以阻止与呼吸暂停相关的心率减慢。三名在家接受吸氧的患者的呼吸暂停时间百分比减少了 60% 以上。这些患者对急性高氧给药也有反应，呼吸暂停时间减少了 60% 以上。一名患者延长了呼吸暂停时间，一名患者的阳性反应极小，两者都再次反映了他们的急性研究。这些数据表明，该综合征呼吸暂停期间发生的严重低氧血症具有中枢通气效应，可传播呼吸暂停，并可通过高氧显着逆转。
Eight adult patients with sleep apnea were studied to evaluate the ventilatory and cardiac effects of hyperoxia on an acute basis. Five patients then used low-flow nighttime oxygen for 30 to 90 days. The results of the acute study showed that for 30-min study periods, the total number of apneas and per cent apnea time (duration of apneas divided by sleep time) decreased significantly from the room air to the oxygen period (207 to 68, p less than 0.05; 41.1 +/- 18.3% SD to 20.5 +/- 14.4%, p less than 0.05, respectively). Also, the apnea-associated slowing in heart rate is blocked by the supplemental oxygen. Three patients receiving oxygen at home decreased their per cent apnea time by greater than 60%. These patients also responded to the acute administration of hyperoxia by a decrease in apnea time greater than 60%. One patient prolonged the apnea time, and one had a minimal positive response, both again reflecting their acute studies. These data suggested that the severe hypoxemia that develops during an apnea in this syndrome has a central ventilatory effect that propagates the apneas and is significantly reversed by hyperoxia.