The etiological role of allogeneic fetal rejection in pre-eclampsia
The etiological role of allogeneic fetal rejection in pre-eclampsia
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DOI：
10.1111/j.1600-0897.2007.00484.x
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发表时间：
2007-07-01
影响因子：
3.6
通讯作者：
Udagawa, Yasuhiro
中科院分区：
文献类型：
--
作者：
Nishizawa, Haruki;Hasegawa, Kiyoshi;Udagawa, Yasuhiro
已有研究表明，胎盘吲哚胺2，3-双加氧酶(IDO)可预防正常妊娠的同种异体胎儿排斥反应。结果重度子痫前期患者胎盘IDO基因表达水平和酶活性水平均较低。酶的活性也与患者的血压呈负相关。在重度子痫前期胎盘中，IDO免疫反应较低，而区域T细胞的浸润与IDO活性成反比。结论IDO活性和母体免疫反应在先兆子痫的发病机制中具有潜在作用。
Problem It has been demonstrated that allogeneic fetal rejection in normal pregnancy is prevented by placental indoleamine 2,3-dioxygenase (IDO). Further, an immunological etiology has been implicated in pre-eclampsia.Methods of study We examined the differences in placental IDO activity between normal and pre-eclamptic pregnancies.Results IDO mRNA expression and enzyme activity levels in the placenta were low in patients with severe pre-eclampsia. The enzyme activity also inversely correlates with the blood pressure of the patients. In the placentas from severe pre-eclampsia, IDO immunoreactivity was low, whereas regional T-cell infiltration was observed reciprocally proportional to the IDO activity.Conclusion Our findings implicate a potential role for IDO activity and a maternal immunological reaction against an allogeneic fetus in the etiology of pre-eclampsia.