ENHANCEMENT OF 2-ACETYLAMINOFLUORENE LIVER CARCINOGENESIS IN RATS FED A CHOLINE-DEVOID DIET
ENHANCEMENT OF 2-ACETYLAMINOFLUORENE LIVER CARCINOGENESIS IN RATS FED A CHOLINE-DEVOID DIET
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DOI：
10.1002/ijc.2910230419
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发表时间：
1979-01-01
影响因子：
6.4
通讯作者：
SHINOZUKA, H
中科院分区：
文献类型：
--
作者：
LOMBARDI, B;SHINOZUKA, H
The effects of feeding a choline-devoid (CD) or a choline-supplemented (CS) diet on the induction of liver tumors in rats by 2-acetylaminofluorene (AAF) were investigated. Male Sprague-Dawley rats were fed either a CD or CS diet containing 0.0075% AAF. Three to 8 animals were killed 1, 3, 4 and 6 mo. thereafter. Well to moderately well differentiated hepatocellular carcinomas developed in 50% and 75% of rats fed the CD + AAF diet for 4 and 6 mo., respectively. Cholangiocarcinomas developed, after 6 mo. in 38% of the animals. No tumor developed in rats fed the CS + AAF diet. The results extend to AAF those previously obtained with DL-ethionine and azaserine showing that feeding a CD diet greatly potentiates the induction in rats of liver tumors by chemical carcinogens.
