HEALTH CONDITIONS ASSOCIATED WITH AGING AND END OF LIFE OF ADULTS WITH DOWN SYNDROME
HEALTH CONDITIONS ASSOCIATED WITH AGING AND END OF LIFE OF ADULTS WITH DOWN SYNDROME
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DOI：
10.1016/s0074-7750(10)39004-5
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Esbensen, Anna J.
中科院分区：
文献类型：
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作者：
Esbensen, Anna J.
对唐氏综合症(DS)患者的生命过程的预期已经改变，预期寿命从1949年的12岁增加到今天的近60岁(Bittle&Glasson，2004；PenRose，1949)。伴随着预期寿命延长的是更多患有DS的成年人，他们的健康表现出与年龄相关的过早变化。因此，有必要为患有DS的成年人这一老龄化人口提供专门的医疗保健，他们在某些情况下风险较高，而在其他情况下风险较低。这篇综述集中在成人DS患者中常见的或显示出随年龄变化的疾病的发生率和促成因素。对医疗条件的审查包括皮肤和头发变化、早发性更年期、视力和听力障碍、成人发作癫痫障碍、甲状腺功能障碍、糖尿病、肥胖、睡眠呼吸暂停和肌肉骨骼问题的风险增加。不同的条件模式与成人DS的死亡率也进行了综述。
Expectations for the life course of individuals with Down syndrome (DS) have changed, with life expectancy estimates increasing from 12 in 1949 to nearly 60 years of age today (Bittles & Glasson, 2004; Penrose, 1949). Along with this longer life expectancy comes a larger population of adults with DS who display premature age-related changes in their health. There is thus a need to provide specialized health care to this aging population of adults with DS who are at high risk for some conditions and at lower risk for others. This review focuses on the rates and contributing factors to medical conditions that are common in adults with DS or that show changes with age. The review of medical conditions includes the increased risk for skin and hair changes, early-onset menopause, visual and hearing impairments, adult-onset seizure disorder, thyroid dysfunction, diabetes, obesity, sleep apnea, and musculoskeletal problems. The different pattern of conditions associated with the mortality of adults with DS is also reviewed.