Early Growth and Body Composition in Infancy
Early Growth and Body Composition in Infancy
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DOI：
10.1007/978-1-4020-9173-5_19
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发表时间：
2009-01-01
期刊：
影响因子：
--
通讯作者：
Fewtrell, Mary S.
中科院分区：
文献类型：
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作者：
Chomtho, Sirinuch;Wells, Jonathan C. K.;Fewtrell, Mary S.
研究婴儿早期生长与身体成分（BC）之间的关系可能为早期营养规划的机制提供线索。作为婴儿营养研究的一部分，1985-1993年在剑桥出生的150名健康足月婴儿（64名男婴）在12周时使用稳定同位素测量了BC。计算男孩和女孩的脂肪质量指数（FMI， FM/长度(2)）和瘦肉质量指数（LMI， LM/长度(2)）内标准差（SDS）。出生体重SDS与12周时的身高、BMI和FMI SDS呈正相关，但LMI SDS不等于出生体重每增加1个SDS， FMI增加0.26个SIDS （95% Cl, 0.04-0.48）。出生-12周体重SDS变化与12周时FMI和LMI SDS呈正相关，相当于体重每增加1个SDS， FMI和LMI分别增加0.68 SDS和0.48 SDS （95% Cl分别为0.48-0.88和0.26-0.70）。相关性与性别、胎次、婴儿饮食以及体重增加、出生体重SDS无关。结论：较高的出生体重与3个月时较高的体重有关，而前3个月的快速体重增加与脂肪和瘦肉质量都有关。我们的数据不支持瘦体重直接从胎儿到童年的假设。
Examination of the relationship between early growth and body composition (BC) in infancy might provide clues about the mechanism of early nutrition programming. 150 healthy full-term infants (64 boys) born in Cambridge from 1985-1993 had BC measured using stable isotope at the age of 12 weeks as a part of infant nutrition studies. Fat mass index (FMI, FM/length(2)) and lean mass index (LMI, LM/length(2)) internal standard deviation scores (SDS) were calculated for boys and girls. Birth weight SDS was positively associated with length, BMI and FMI SDS at 12 weeks, but not LMI SDS equivalent to 0.26 SIDS increase in FMI per I SDS increase in birth weight (95% Cl, 0.04-0.48). Weight SDS change from birth-12 weeks was positively correlated with FMI and LMI SDS at 12 weeks equivalent to 0.68 SDS and 0.48 SDS increase in FMI and LMI per I SDS gain in weight (95% Cl, 0.48-0.88 and 0.26-0.70, respectively). Associations were independent of gender, parity, infant diets, and, for weight gain, birth weight SDS. Conclusion: Higher birth weight was associated with higher feat mass at 3 months whereas rapid weight gain in the first 3 months was associated with both fat and lean mass. Our data do not support the hypothesis that lean mass tracks directly from fetal life to childhood.